Genetic and antigenic diversity of human rotaviruses: potential impact on the success of candidate vaccines.
Genetic and antigenic diversity of human rotaviruses: potential impact on the success of candidate vaccines.
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人类轮状病毒的遗传和抗原多样性：对候选疫苗成功的潜在影响。
DOI：
10.1111/j.1574-6968.1999.tb08819.x
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发表时间：
1999
影响因子：
2.1
通讯作者：
E. Palombo
中科院分区：
文献类型：
--
作者：
E. Palombo
第一个人类轮状病毒疫苗的许可证增加了减少儿科腹泻疾病负担的希望。然而，在发展中国家进行的试验中，这种疫苗的性能不是最佳的，这表明有必要改进疫苗的设计。对从不同地理位置收集的轮状病毒分离株的遗传和抗原多样性的分析表明，未来的疫苗制剂可能需要包括更广泛的毒株。这可以通过提供针对循环病毒的全面覆盖来提高疫苗效力。在引入常规疫苗接种之前和之后对轮状病毒种群进行持续监测和遗传分析将揭示该病原体的多样性是否会影响疫苗项目的成功。
Licensing of the first human rotavirus vaccine raises the hope of a reduction in the burden of paediatric diarrheal disease. However, the less than optimal performance of this vaccine in trials carried out in developing countries indicates that improvements in vaccine design are necessary. Analysis of the genetic and antigenic diversity of rotavirus isolates collected from various geographical locations suggests that future vaccine formulations may need to include a broader spectrum of strains. This may increase vaccine efficacy by providing comprehensive coverage against circulating viruses. Continued surveillance and genetic analysis of the rotavirus population prior to and after the introduction of routine vaccination will reveal if the diversity of this pathogen will impact on the success of vaccine programs.