Right lobe living donor liver transplantation between adults
Right lobe living donor liver transplantation between adults
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DOI：
10.1055/s-2002-30123
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发表时间：
2002-05-17
影响因子：
0.6
通讯作者：
Neuhaus, P
中科院分区：
文献类型：
--
作者：
Steinmüller, T;Pascher, A;Neuhaus, P
背景和目的：在过去的几年中，越来越多的移植中心建立了成人活体肝移植。捐赠者的安全和风险是影响进一步发展的重要标准。方法：从1999年12月至2001年12月，43例终末期肝病患者(平均年龄：49，8，16，0岁；女：男：14：29)接受了成人活体供肝右肝移植(平均年龄：42，4，13，4岁：女：男=27：16)。在计划开始和每一次捐赠之前，都得到了当地伦理委员会的批准。结果：捐赠者没有发生致命或长期的并发症。供者手术并发症(胆漏、出血)发生率为9%。三个月后受者存活率为93%，一年后存活率为88%。5名患者不得不再次移植。因此，移植物1年存活率为79%。胆道并发症发生率为14%。结论：根据我们的经验，活体右肝叶供肝移植是一种安全有效的手术方法。特别是对于急慢性肝功能衰竭的患者，否则他们可能会在等待名单上死亡，这种方法提供了一个拯救生命的选择。
Background and objective: Adult living donor liver transplantation has been established in an increasing number of transplant centres during the last few years. Donor safety and risks are important criteria influencing the further development. We report our experience with 43 adult-to-adult right lobe living donor liver transplantations.Methods: 43 patients (mean age: 49,8 16,0 years; f:m = 14:29) with end-stage liver disease received a right lobe liver graft from an adult living donor (mean age: 42,4 13,4 years: f:m = 27:16) between December 1999 and December 2001. An approval by the local ethics committee was obtained prior to the start of the programme and each donation.Results: None of the donors experienced fatal or long-term complications. The rate of surgical complications in donors (biliary leakage, bleeding) was 9%. Actuarial recipient survival was 93% after three months and 88% after one year. Five patients had to be re-transplanted. Thus the actuarial 1-year graft survival was 79%. Biliary complications occured in 14% of all recipients.Conclusion: According to our experience, living donor liver transplantation of the right hepatic lobe is a safe and effective procedure. Especially for patients in acute and chronic liver failure, who otherwise would have died on the waiting list, this approach offers a life-saving option.