Resting Brain Activity Varies with Dream Recall Frequency Between Subjects
Resting Brain Activity Varies with Dream Recall Frequency Between Subjects
复制标题
DOI：
10.1038/npp.2014.6
复制
发表时间：
2014-06-01
影响因子：
7.6
通讯作者：
Ruby, Perrine
中科院分区：
文献类型：
--
作者：
Eichenlaub, Jean-Baptiste;Nicolas, Alain;Ruby, Perrine
人们对做梦仍然知之甚少。值得注意的是，它的大脑基础仍不清楚。神经心理学研究表明，颞顶交界区(TPJ)和/或内侧前额叶皮质(MPFC)白质的损伤会导致梦境报告的全球停止，这表明默认模式网络的这些区域在做梦过程中发挥关键作用(前脑‘做梦’假说)。为了验证这一假设，我们使用[O-15]H2O正电子发射断层扫描技术测量了健康受试者在清醒(休息)和睡眠(快速眼动(REM)睡眠、氮气和氮气)时的梦回忆频率(DRF)高低的局部脑血流量(RCBF)。与低回忆者(平均每周0.5+/-0.3梦回忆)相比，高回忆者(5.2+/-1.4)在REM睡眠、N3和清醒时的TPJ，以及在REM睡眠和清醒时的MPFC显示更高的rCBF。我们证明了高回忆者和低回忆者在睡眠和清醒时的休息状态不同。它与之前的ERP结果一致，并确认高/低DRF与大脑的特定功能组织相关。这些结果支持前脑“做梦”假说，并表明TPJ和MPFC不仅参与清醒时的梦回忆，而且在睡眠时做梦(产生和/或编码)也有作用。TPJ和MPFC中活动的增加可能会促进梦的心理意象和/或记忆编码。值得注意的是，TPJ的活动增加可能会促进注意力转向外部刺激，并促进睡眠中的觉醒，从而促进记忆中对梦的编码。
Dreaming is still poorly understood. Notably, its cerebral underpinning remains unclear. Neuropsychological studies have shown that lesions in the temporoparietal junction (TPJ) and/or the white matter of the medial prefrontal cortex (MPFC) lead to the global cessation of dream reports, suggesting that these regions of the default mode network have key roles in the dreaming process (forebrain 'dream-on' hypothesis). To test this hypothesis, we measured regional cerebral blood flow (rCBF) using [O-15]H2O positron emission tomography in healthy subjects with high and low dream recall frequencies (DRFs) during wakefulness (rest) and sleep (rapid eye movement (REM) sleep, N2, and N3). Compared with Low recallers (0.5 +/- 0.3 dream recall per week in average), High recallers (5.2 +/- 1.4) showed higher rCBF in the TPJ during REM sleep, N3, and wakefulness, and in the MPFC during REM sleep and wakefulness. We demonstrate that the resting states of High recallers and Low recallers differ during sleep and wakefulness. It coheres with previous ERP results and confirms that a high/low DRF is associated with a specific functional organization of the brain. These results support the forebrain 'dream-on' hypothesis and suggest that TPJ and MPFC are not only involved in dream recall during wakefulness but also have a role in dreaming during sleep (production and/or encoding). Increased activity in the TPJ and MPFC might promote the mental imagery and/or memory encoding of dreams. Notably, increased activity in TPJ might facilitate attention orienting toward external stimuli and promote intrasleep wakefulness, facilitating the encoding of the dreams in memory.