"Dirty Dancing" of Calcium and Autophagy in Alzheimer's Disease.
"Dirty Dancing" of Calcium and Autophagy in Alzheimer's Disease.
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DOI：
10.3390/life13051187
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发表时间：
2023-05-15
期刊：
影响因子：
--
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中科院分区：
文献类型：
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阿尔茨海默病（AD）是痴呆症最常见的原因。越来越多的证据表明，神经元钙（Ca2+）信号的失调在阿尔茨海默病的发病机制中起着重要作用。特别是，已经确定的Ryanodine受体（RyanR）表达水平在AD神经元中增加，Ca2+通过RyanR释放在AD神经元中增加。自噬对于去除不必要的或功能失调的成分和长寿命的蛋白质聚集体很重要，AD神经元的自噬损伤已被广泛报道。在这篇综述中，我们讨论了最近的结果表明细胞内Ca2+信号和溶酶体/自噬失调之间的因果关系。这些新结果为阿尔茨海默病的发病机制提供了新的见解，并可能导致发现治疗阿尔茨海默病和其他神经退行性疾病的新治疗靶点。
Alzheimer’s disease (AD) is the most common cause of dementia. There is a growing body of evidence that dysregulation in neuronal calcium (Ca2+) signaling plays a major role in the initiation of AD pathogenesis. In particular, it is well established that Ryanodine receptor (RyanR) expression levels are increased in AD neurons and Ca2+ release via RyanRs is augmented in AD neurons. Autophagy is important for removing unnecessary or dysfunctional components and long-lived protein aggregates, and autophagy impairment in AD neurons has been extensively reported. In this review we discuss recent results that suggest a causal link between intracellular Ca2+ signaling and lysosomal/autophagic dysregulation. These new results offer novel mechanistic insight into AD pathogenesis and may potentially lead to identification of novel therapeutic targets for treating AD and possibly other neurodegenerative disorders.
影响因子：
4.8
作者：
Jensen LE;Bultynck G;Luyten T;Amijee H;Bootman MD;Roderick HL
通讯作者：
Roderick HL