Adhesion molecules in cancer: the role of integrins
Adhesion molecules in cancer: the role of integrins
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DOI：
10.1016/0955-0674(93)90030-t
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发表时间：
1993-10-01
影响因子：
7.5
通讯作者：
Varner, Judy A.
中科院分区：
文献类型：
--
作者：
Juliano, Rudy L.;Varner, Judy A.
一段时间以来，人们已经知道细胞粘附受体，包括整合素家族的成员，在肿瘤生物学中发挥重要作用。直到最近，在这一领域的研究重点关注的是整合素作为粘附分子在恶性细胞的侵袭和转移行为中的功能。现在已经清楚，整合素可以作为真正的受体，能够将信号转导到细胞内部。酪氨酸磷酸化似乎是整合素介导的信号转导的一个关键方面，并且已经描述了一种新的酪氨酸激酶，其似乎在该过程中很重要。越来越多的证据表明，整合素介导的信号可以诱导基因表达，并影响通过细胞周期的运输。因此，整联蛋白在癌症中的作用似乎不仅涉及细胞粘附事件，而且还可能涉及肿瘤细胞生长和分化的调节。
It has been known for some time that cell adhesion receptors, including members of the integrin family, play an important role in the biology of tumors. Until recently, most of the emphasis in this area of research has concerned the functioning of integrins as adhesive molecules in the invasive and metastatic behavior of malignant cells. Now it has become clear that integrins can function as true receptors capable of transducing signals to the cell interior. Tyrosine phosphorylation seems to be a key aspect of integrin-mediated signal transduction, and a new tyrosine kinase has been described that seems to be important in this process. Evidence is accumulating that integrin-mediated signals can induce gene expression and affect transit through the cell cycle. Thus, the role of integrins in cancer seems not only to involve cell adhesion events, but may also involve the regulation of tumor cell growth and differentiation.