Trends and patterns of antidepressant use in children and adolescents from five western countries, 2005-2012
Trends and patterns of antidepressant use in children and adolescents from five western countries, 2005-2012
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DOI：
10.1016/j.euroneuro.2016.02.001
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发表时间：
2016-03-01
影响因子：
5.6
通讯作者：
Hoffmann, Falk
中科院分区：
文献类型：
--
作者：
Bachmann, Christian J.;Aagaard, Lise;Hoffmann, Falk
在2004年FDA发出黑箱警告后，在几个国家的儿童和青少年中，在两年内观察到抗抑郁药（ATD）的使用大幅减少。然而，这些减少是否持续尚不清楚。本研究的目的是利用从丹麦、德国、荷兰、英国和美国的区域或国家数据库中提取的数据，评估2005/6-2012历年青年（0-19岁）使用ATD的最新趋势。在重复横断面设计中，计算ATD使用的年患病率，并根据年龄、性别、亚类和特定药物进行分层。多年来，美国数据显示，ATD使用率从1.3%上升到1.6% (+26.1%)；英国数据0.7% - 1.1% (+54.4%)；丹麦数据为0.6% - 1.0% (+60.5%)；荷兰数据为0.5% - 0.6% (+17.6%)；德国数据为0.3% - 0.5%（+49.2%）。丹麦、德国和英国15-19岁人群的相对增长最大，荷兰和美国10-14岁人群的相对增长最大。虽然SSRIs是最常用的ATDs，特别是在丹麦（占所有ATDs的81.8%），但德国和英国仍然显示三环类抗抑郁药的使用比例显著（分别为23.0%和19.5%）。尽管在政府发出警告后，ATD的使用突然下降，但这一趋势并没有持续下去，相反，近年来，在五个西方国家的青年群体中，儿童和青少年使用ATD的人数大幅增加。(C) 2016 Elsevier B.V.和ECNP。版权所有。
Following the FDA black box warning in 2004, substantial reductions in antidepressant (ATD) use were observed within 2 years in children and adolescents in several countries. However, whether these reductions were sustained is not known. The objective of this study was to assess more recent trends in ATD use in youth (0-19 years) for the calendar years 2005/6-2012 using data extracted from regional or national databases of Denmark, Germany, the Netherlands, the United Kingdom (UK), and the United States (US). In a repeated cross-sectional design, the annual prevalence of ATD use was calculated and stratified by age, sex, and according to subclass and specific drug. Across the years, the prevalence of ATD use increased from 1.3% to 1.6% in the US data (+26.1%); 0.7% to 1.1% in the UK data (+54.4%); 0.6% to 1.0% in Denmark data (+60.5%); 0.5% to 0.6% in the Netherlands data (+17.6%); and 0.3% to 0.5% in Germany data (+49.2%). The relative growth was greatest for 15-19 year olds in Denmark, Germany and UK cohorts, and for 10-14 year olds in Netherlands and US cohorts. While SSRIs were the most commonly used ATDs, particularly in Denmark (81.8% of all ATDs), Germany and the UK still displayed notable proportions of tricyclic antidepressant use (23.0% and 19.5%, respectively). Despite the sudden decline in ATD use in the wake of government warnings, this trend did not persist, and by contrast, in recent years, ATD use in children and adolescents has increased substantially in youth cohorts from five Western countries. (C) 2016 Elsevier B.V. and ECNP. All rights reserved.