POSTNATAL NUTRITIONAL-STATUS INFLUENCES DEVELOPMENT OF CARDIAC ADRENERGIC-RECEPTOR BINDING-SITES
POSTNATAL NUTRITIONAL-STATUS INFLUENCES DEVELOPMENT OF CARDIAC ADRENERGIC-RECEPTOR BINDING-SITES
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DOI：
10.1016/0361-9230(88)90023-8
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发表时间：
1988-12-01
影响因子：
3.8
通讯作者：
SLOTKIN, TA
中科院分区：
文献类型：
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作者：
BELL, JM;SLOTKIN, TA
通过改变窝仔数以产生营养过剩（5-6只幼仔/窝）和营养不良动物（16-17只幼仔/窝），与标准营养状态（10-11只幼仔/窝）进行比较，从而控制新生大鼠的营养状态。营养缺乏的幼仔显示出身体和心脏生长受损以及α 1-和β-的心肌膜结合位点发育减慢。受体配体营养过剩促进生长和受体发育。在所有情况下，受体结合特征恢复正常发生在营养恢复开始时（即，在断奶时），在体重和器官重量恢复之前。因此，这些结果表明，受体结合位点的个体发育模式是依赖于营养摄入，而不是体重增加本身。新生儿营养不良引起的受体缺陷可能有助于降低反应肾上腺素能刺激。
Nutritional status in neonatal rats was manipulated by altering the litter size to produce overnourished (5-6 pups/litter) and undernourished animals (16-17 pups/litter) for comparison with standard nutritive status (10-11 pups/litter). Nutritionally deprived pups showed impaired body and cardiac growth and a slowing of development of cardiac membrane binding sites for .alpha.1- and .beta.-receptor ligands. Overnourishment enhanced growth and receptor development. In all cases, restitution of receptor binding characteristics to normal occurred at the beginning of nutritional rehabilitation (i.e., at weaning), well before the return of body and organ weights. These results thus suggest that the ontogenetic pattern of receptor binding sites is dependent upon nutritional intake rather than on weight gains per se. Receptor deficits caused by neonatal malnutrition probably contribute to reduced responsiveness to adrenergic stimulation.