Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: Is 2-arachidonoylglycerol a possible vasomodulator?
Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: Is 2-arachidonoylglycerol a possible vasomodulator?
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DOI：
10.1006/bbrc.1998.8187
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发表时间：
1998-02-24
影响因子：
3.1
通讯作者：
Waku, K
中科院分区：
文献类型：
--
作者：
Sugiura, T;Kodaka, T;Waku, K
发现人血管内皮细胞在用凝血酶或A23187刺激后产生并释放2-花生四烯酸甘油，其是内源性大麻素受体配体。我们证实，血管平滑肌细胞以及内皮细胞具有大麻素CB 1受体mRNA。在血管组织中产生的2-花生四烯酰甘油可能通过作用于血管平滑肌细胞、内皮细胞以及外周神经末梢上表达的大麻素CB 1受体而在调节血管张力中发挥重要作用。(C)北京：科学出版社.
Human vascular endothelial cells were found to generate and release 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, upon stimulation with thrombin or A23187. We confirmed that vascular smooth muscle cells as well as endothelial cells possess cannabinoid CB1 receptor mRNA. 2-Arachidonoylglycerol, generated in vascular tissues, may play an important role in modulating vascular tone through acting on the cannabinoid CB1 receptor expressed on vascular smooth muscle cells, endothelial cells as well as peripheral nerve terminals. (C) 1998 Academic Press.