Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies
Correlation of early-phase 18F-florbetapir (AV-45/Amyvid) PET images to FDG images: preliminary studies
复制标题
DOI：
10.1007/s00259-011-2051-2
复制
发表时间：
2012-04-01
影响因子：
9.1
通讯作者：
Lin, Kun-Ju
中科院分区：
文献类型：
--
作者：
Hsiao, Ing-Tsung;Huang, Chin-Chang;Lin, Kun-Ju
F-18-Florbetapir（AV-45/Amyvid）是一种新型的正电子发射断层扫描（PET）示踪剂，可用于阿尔茨海默病（AD）斑块病理学成像，而氟脱氧葡萄糖（FDG）的脑葡萄糖代谢PET图像可为淀粉样斑块图像提供补充信息，用于AD的诊断。本初步研究的目的是研究相对脑血流量估计值（R-1）和早期AV-45图像[灌注AV-45（pAV-45）]的总和的灌注样性质，并优化pAV-45的早期时间范围。对7名受试者进行动态AV-45 PET扫描（0-180 min）。pAV-45、晚期AV-45和FDG图像在单个MRI图像的辅助下空间标准化为蒙特利尔神经学研究所模板，并计算相应的标准化摄取值比率（SUVR）。R-1图像来源于简化的参考组织模型。计算区域和体素R-1与相应FDG图像之间的相关性。根据与FDG图像的相关性，对pAV-45的时间范围进行优化。最佳的早期时间范围在一个单独的队列中进行了验证，在R-1图像的区域分布相关良好（R = 0.91），在受试者内的FDG。在很长的时间范围内，注意到一致的高相关性。pAV-45与FDG SUVR的相关性在1-6 min时达到最大，R = 0.95，而在0-2 min时达到最大，R = 0.99。初步结果表明，R-1和pAV-45图像的分布模式与标准化FDG图像高度相关，并且1-6 min的初始5 min早期时间范围可能有助于通过后期AV-45图像为淀粉样斑块密度提供补充FDG样信息。
F-18-Florbetapir (AV-45/Amyvid) is a novel positron emission tomography (PET) tracer for imaging plaque pathology in Alzheimer's disease (AD), while PET images of fluorodeoxyglucose (FDG) for cerebral glucose metabolism can provide complementary information to amyloid plaque images for diagnosis of AD. The goal of this preliminary study was to investigate the perfusion-like property of relative cerebral blood flow estimates (R-1) and summed early-phase AV-45 images [perfusion AV-45 (pAV-45)] and optimize the early time frame for pAV-45.Dynamic AV-45 PET scans (0-180 min) were performed in seven subjects. pAV-45, late-phase AV-45, and FDG images were spatially normalized to the Montreal Neurological Institute template aided by individual MRI images, and the corresponding standardized uptake value ratio (SUVR) was computed. The R-1 images were derived from a simplified reference tissue model. Correlations between regional and voxelwise R-1 and the corresponding FDG images were calculated. An optimization of time frames of pAV-45 was conducted in terms of correlation to FDG images. The optimal early time frame was validated in a separate cohort.The regional distribution in the R-1 images correlated well (R = 0.91) to that of the FDG within subjects. Consistently high correlation was noted across a long range of time frames. The maximal correlation of pAV-45 to FDG SUVR of R = 0.95 was observed at the time frame of 1-6 min, while the peak correlation of R = 0.99 happened at 0-2 min between pAV-45 and R-1. A similar result was achieved in the validation cohort.Preliminary results showed that the distribution patterns of R-1 and pAV-45 images are highly correlated with normalized FDG images, and the initial 5-min early time frame of 1-6 min is potentially useful in providing complementary FDG-like information to the amyloid plaque density by late-phase AV-45 images.