Quantitative evaluation of transdermal drug delivery patches on human skin with in vivo THz-TDS.
Quantitative evaluation of transdermal drug delivery patches on human skin with in vivo THz-TDS.
复制标题
使用体内 THz-TDS 对人体皮肤上的透皮给药贴片进行定量评估。
DOI：
10.1364/boe.473097
复制
发表时间：
2023-03-01
影响因子：
3.4
通讯作者：
Pickwell-macpherson, Emma
中科院分区：
文献类型：
--
作者：
Ding, X. U. E. F. E., I;Costa, Goncalo;Hernandez-serrano, I.;Stantchev, Rayko I.;Nurumbetov, Gabit;Haddleton, David M.;Pickwell-macpherson, Emma
经皮给药（TDD）由于具有稳定的给药速率等优点，在医学治疗中得到了广泛的应用。然而，皮肤水合作用的变化会对化学物质的渗透性产生重大影响。因此，研究TDD贴片引起的皮肤水化变化，以更好地控制给药速率是必要的。在这项工作中，体内太赫兹（THz）光谱用于定量监测应用不同背衬材料和丙二醇浓度的贴片后的人体皮肤。皮肤水合作用的变化和皮肤对其他贴片引起的闭塞的反应进行了研究和比较。我们的工作证明了体内太赫兹测量在人体皮肤透皮贴片无标签、无创评估中的潜在应用，并进一步揭示了这种效应背后的机制。
Transdermal drug delivery (TDD) has been widely used in medical treatments due to various advantages, including delivering drugs at a consistent rate. However, variations in skin hydration can have a significant effect on the permeability of chemicals. Therefore, it is essential to study the changes in skin hydration induced by TDD patches for better control of the delivery rate. In this work, in vivo terahertz (THz) spectroscopy is conducted to quantitatively monitor human skin after the application of patches with different backing materials and propylene glycol concentrations. Changes in skin hydration and skin response to occlusion induced by other patches are investigated and compared. Our work demonstrates the potential application of in vivo THz measurements in label-free, non-invasive evaluation of transdermal patches on human skin and further reveals the mechanism behind the effect.