Global trends in molecular epidemiology of HIV-1 during 2000-2007.
Global trends in molecular epidemiology of HIV-1 during 2000-2007.
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DOI：
10.1097/qad.0b013e328342ff93
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发表时间：
2011-03-13
期刊：
影响因子：
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通讯作者：
WHO-UNAIDS Network for HIV Isolation and Characterisation
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文献类型：
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作者：
Hemelaar J;Gouws E;Ghys PD;Osmanov S;WHO-UNAIDS Network for HIV Isolation and Characterisation
估计2000年至2007年间HIV-1亚型和重组的全球和区域分布。各国特有的艾滋病毒-1分子流行病学数据与每个国家艾滋病毒感染人数的估计数相结合。在2000年至2007年期间，从109个国家的65913个样本中收集了HIV-1亚型的横断面数据。艾滋病毒-1亚型在各国的分布情况根据每个国家感染艾滋病毒的人数进行加权，从而得出2000-2003年和2004-2007年期间区域和全球艾滋病毒-1亚型分布情况的估计数。对这两个时间段内HIV-1亚型和重组体的全球分布的分析表明，HIV-1亚型在全球范围内的分布大致稳定，循环重组形式（crf）的比例显著增加，独特重组形式（urf）的比例显著减少，重组体的总体增加。2004-2007年，C亚型占全球所有感染的近一半（48%），其次是A亚型（12%）和B亚型（11%），CRF02_AG (8%), CRF01_AE (5%)， G亚型（5%）和D亚型（2%）。F、H、J和K亚型加起来在全世界造成的感染不到1%。其他crf和urf各占全球感染的4%，使全球crf总数达到16%，所有重组（crf加urf）总数达到20%。个别亚型和重组的全球和区域分布大致稳定，尽管CRFs可能在艾滋病毒大流行中发挥越来越大的作用。艾滋病毒-1的全球多样性对艾滋病毒疫苗的开发构成了巨大挑战。
To estimate the global and regional distribution of HIV-1 subtypes and recombinants between 2000 and 2007. Country-specific HIV-1 molecular epidemiology data were combined with estimates of the number of HIV-infected people in each country. Cross-sectional HIV-1 subtyping data were collected from 65913 samples in 109 countries between 2000 and 2007. The distribution of HIV-1 subtypes in individual countries was weighted according to the number of HIV-infected people in each country to generate estimates of regional and global HIV-1 subtype distribution for the periods 2000–2003 and 2004–2007. Analysis of the global distribution of HIV-1 subtypes and recombinants in the two time periods indicated a broadly stable distribution of HIV-1 subtypes worldwide with a notable increase in the proportion of circulating recombinant forms (CRFs), a decrease in unique recombinant forms (URFs), and an overall increase in recombinants. In 2004–2007, subtype C accounted for nearly half (48%) of all global infections, followed by subtypes A (12%) and B (11%), CRF02_AG (8%), CRF01_AE (5%), subtype G (5%) and D(2%). Subtypes F, H, J and K together cause fewer than 1% of infections worldwide. Other CRFs and URFs are each responsible for 4% of global infections, bringing the combined total of worldwide CRFs to 16% and all recombinants (CRFs plus URFs) to 20%. The global and regional distributions of individual subtypes and recombinants are broadly stable, although CRFs may play an increasing role in the HIV pandemic. The global diversity of HIV-1 poses a formidable challenge to HIV vaccine development.