Famous faces and voices: Differential profiles in early right and left semantic dementia and in Alzheimer's disease
Famous faces and voices: Differential profiles in early right and left semantic dementia and in Alzheimer's disease
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DOI：
10.1016/j.neuropsychologia.2016.11.020
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发表时间：
2017-01-08
期刊：
影响因子：
2.6
通讯作者：
Gainotti, Guido
中科院分区：
文献类型：
--
作者：
Luzzi, Simona;Baldinelli, Sara;Gainotti, Guido
背景资料：据报道，在语义性痴呆（SD）和阿尔茨海默病（AD）中，著名的面孔和声音识别都会受损，尽管前者更为严重。在AD中，还报告了面部和语音处理中的感知障碍的共存，这可能有助于在复杂的语义任务中改变性能。另一方面，在SD中，面孔和声音识别障碍可能与右颞叶（RTL）萎缩的患病率有关。目的：本研究的目的是双重的：（1）调查SD和AD的著名面孔和声音识别，以验证这两种疾病是否表现出不同的损害模式，由于不同的认知机制的破坏;（2）检查是否存在主要影响RTL的萎缩患者的面部和声音识别障碍。材料：为了避免面部和声音识别的主要感知问题的潜在影响，对早期SD和AD患者进行了一组详细的面部和声音感知测试。最终选择了13名SD患者（8名右颞叶萎缩，5名左颞叶萎缩）和25名CE患者，他们没有表现出视觉和听觉感知障碍，并进行了一系列探索著名面孔和声音识别和命名的实验。12例SD患者接受了脑PET成像，并根据发病方式和右或左颞叶FDG摄取普遍下降分别分为右和左SD。PET成像和著名的面孔和声音recognition.Results的相关性：结果显示，在这两种疾病的差异性能配置文件，因为AD患者显着受损的命名测试，但显示保留识别，而SD患者的命名和著名的面孔和声音的识别都严重受损。此外，面部和声音识别障碍在伴有RTL萎缩的SD患者中普遍存在，这些患者在金字塔和棕榈树测试中也表现出概念障碍，其在图片中的重要性大于在口头modality.Finally，在12 SD患者中，PET可用，FDG摄取与脸对名字和声音对声音之间的强相关性。在右侧颞叶中发现了姓名匹配数据，但在左侧颞叶中未发现。这些数据支持这一假设，即两种痴呆症的面孔和声音识别障碍的认知基础不同，并表明SD的障碍模式可能是由于语义表征的丧失，而语义控制的缺陷，命名受损和保留的识别可能是AD的假设。此外，面部和语音识别障碍和RTL损害之间的相关性是一致的假设，假设在RTL的个人特定的知识可能主要是基于非言语表征。
Background: Famous face and voice recognition is reported to be impaired both in semantic dementia (SD) and in Alzheimer's Disease (AD), although more severely in the former. In AD a coexistence of perceptual impairment in face and voice processing has also been reported and this could contribute to the altered performance in complex semantic tasks. On the other hand, in SD both face and voice recognition disorders could be related to the prevalence of atrophy in the right temporal lobe (RTL).Objective: The aim of the present study was twofold: (1) to investigate famous faces and voices recognition in SD and AD to verify if the two diseases show a differential pattern of impairment, resulting from disruption of different cognitive mechanisms; (2) to check if face and voice recognition disorders prevail in patients with atrophy mainly affecting the RTL.Materials: To avoid the potential influence of primary perceptual problems in face and voice recognition, a pool of patients suffering from early SD and AD were administered a detailed set of tests exploring face and voice perception. Thirteen SD (8 with prevalence of right and 5 with prevalence of left temporal atrophy) and 25 CE patients, who did not show visual and auditory perceptual impairment, were finally selected and were administered an experimental battery exploring famous face and voice recognition and naming. Twelve SD patients underwent cerebral PET imaging and were classified in right and left SD according to the onset modality and to the prevalent decrease in FDG uptake in right or left temporal lobe respectively. Correlation of PET imaging and famous face and voice recognition was performed.Results: Results showed a differential performance profile in the two diseases, because AD patients were significantly impaired in the naming tests, but showed preserved recognition, whereas SD patients were profoundly impaired both in naming and in recognition of famous faces and voices. Furthermore, face and voice recognition disorders prevailed in SD patients with RTL atrophy, who also showed a conceptual impairment on the Pyramids and Palm Trees test more important in the pictorial than in the verbal modality.Finally, in 12SD patients in whom PET was available, a strong correlation between FDG uptake and face-to name and voice-to-name matching data was found in the right but not in the left temporal lobe.Discussion: The data support the hypothesis of a different cognitive basis for impairment of face and voice recognition in the two dementias and suggest that the pattern of impairment in SD may be due to a loss of semantic representations, while a defect of semantic control, with impaired naming and preserved recognition might be hypothesized in AD. Furthermore, the correlation between face and voice recognition disorders and RTL damage are consistent with the hypothesis assuming that in the RTL person-specific knowledge may be mainly based upon non-verbal representations.