COMPARISON OF DIRECT AND INDIRECT MEASUREMENTS OF PULMONARY CAPILLARY TRANSIT TIMES
COMPARISON OF DIRECT AND INDIRECT MEASUREMENTS OF PULMONARY CAPILLARY TRANSIT TIMES
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DOI：
10.1152/jappl.1987.62.3.1150
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发表时间：
1987-03-01
影响因子：
3.3
通讯作者：
WAGNER, WW
中科院分区：
文献类型：
--
作者：
CAPEN, RL;LATHAM, LP;WAGNER, WW
使用活体显微镜，我们通过确定荧光染料从狗肺依赖表面的小动脉传递到小静脉所需的时间，直接测量了肺毛细血管传递时间。同时，在同一动物中，采用弥散容量法（毛细血管血容量除以心输出量）间接测量全肺的肺毛细血管传递时间。在一组5只狗中，每种方法的过境时间相同[直接：1.75 .+-。]0.27 (SE) s；间接：1.85。0.33年代;P = 0.7]。这些传递时间的相似性是重要的，因为广泛使用的基于扩散能力的间接测定现在被证明与直接测量一致，也因为它表明依赖肺表面的毛细血管传递时间的测量与肺其余部分毛细血管的测量具有有用的关系。
Using in vivo microscopy, we made direct measurements of pulmonary capillary transit time by determining the time required for fluorescent dye to pass from an arteriole to a venule on the dependent surface of the dog lung. Concurrently, in the same animals, pulmonary capillary transit time was measured indirectly in the entire lung using the diffusing capacity method (capillary blood volume divided by cardiac output). Transit times by each method were the same in a group of five dogs [direct: 1.75 .+-. 0.27 (SE) s; indirect: 1.85 .+-. 0.33 s; P = 0.7]. The similarity of these transit times is important, because the widely used indirect determinations based on diffusing capacity are now shown to coincide with direct measurements and also because it demonstrates that measurements of capillary transit times on the surface of the dependent lung bear a useful relationship to measurments on the capillaries in the rest of the lung.