Rhythmic daily shedding of outer-segment membranes by visual cells in the goldfish
Rhythmic daily shedding of outer-segment membranes by visual cells in the goldfish
复制标题
金鱼视觉细胞每天有节奏地脱落外节膜
DOI：
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发表时间：
1978
影响因子：
7.8
通讯作者：
Richard W. Young
中科院分区：
文献类型：
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作者：
Richard W. Young
将金鱼置于 12 小时光照和 12 小时黑暗的每日光照周期中 18 天或更长时间。然后在整个周期的许多时间间隔通过显微镜检查视网膜的视细胞和色素上皮。金鱼的视杆和视锥遵循有节奏的模式，从其外部节段消除光敏膜包。杆细胞在光照期早期就脱落膜。脱落的膜被色素上皮细胞或阿米巴吞噬细胞吞噬，在光照期间的剩余时间内将其降解。在黑暗期的早期，视锥细胞会从其外节末端丢弃膜。在接下来的几个小时内，这些碎片被色素上皮或阿米巴吞噬细胞消化。因此，外段更新过程的处置阶段在杆和锥中是相似的，但在时间上位移了约12小时。有证据表明，视杆细胞和视锥细胞膜的这种日常节律是脊椎动物视觉细胞的普遍特性。
Goldfish were placed on a daily light cycle of 12 h light and 12 h darkness for 18 days or longer. The visual cells and pigment epithelium of the retina were then examined by microscopy at many intervals throughout the cycle. Goldfish rods and cones follow a rhythmic pattern in eliminating packets of photosensitive membranes from their outer segments. Rods shed membranes early in the light period. The detached membranes are ingested by pigment epithelial cells or by ameboid phagocytes, which degrade them during the remainder of the light period. Cones discard membranes from the ends of their outer segments early in the dark period. During the next several hours, this debris is digested by the pigment epithelium or by ameboid phagocytes. Thus, the disposal phase of the outer-segment renewal process is similar in rods and cones, but is displaced in time by about 12 h. There is evidence that this daily rhythm of membrane disposal in rods and cones is a general property of vertebrate visual cells.