Modeling the active sites of bacteriophage T7 lysozyme, bovine 5-aminolevulinate dehydratase, and peptide deformylase:: synthesis and structural characterization of a bis(pyrazolyl)(thioalkoxy)hydroborato zinc complex, [(Ph2CHS)BpBu-t,Pr-i]ZnI
Modeling the active sites of bacteriophage T7 lysozyme, bovine 5-aminolevulinate dehydratase, and peptide deformylase:: synthesis and structural characterization of a bis(pyrazolyl)(thioalkoxy)hydroborato zinc complex, [(Ph2CHS)BpBu-t,Pr-i]ZnI
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DOI：
10.1039/a707444a
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发表时间：
1998-02-07
影响因子：
4.9
通讯作者：
Parkin, G
中科院分区：
文献类型：
--
作者：
Ghosh, P;Parkin, G
将硫代二苯甲酮插入到[Bp（But，Pri）]ZnI的B-H键中，实现了[（Ph 2CHS）Bp（But，Pri）]ZnI的合成，该复合物中原位产生的[NNS]供体配体模拟了噬菌体T7溶菌酶、牛5-氨基乙酰丙酸酯酶和肽脱甲酰基酶的活性位点处的组氨酸和半胱氨酸残基的结合。
Insertion of thiobenzophenone into a B-H bond of [Bp(But,Pri)]ZnI achieves the synthesis of [(Ph2CHS)Bp(But,Pri)]ZnI, a complex in which the in situ generated [NNS] donor ligand models the binding of the histidine and cysteine residues at the active sites of bacteriophage T7 lysozyme, bovine 5-aminolevulinate dehydratase and peptide deformylase.