Cognitive phenotypes in childhood idiopathic epilepsies.
Cognitive phenotypes in childhood idiopathic epilepsies.
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DOI：
10.1016/j.yebeh.2016.05.013
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发表时间：
2016-08
期刊：
影响因子：
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通讯作者：
Rathouz PJ
中科院分区：
文献类型：
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作者：
Hermann BP;Zhao Q;Jackson DC;Jones JE;Dabbs K;Almane D;Hsu DA;Stafstrom CE;Koehn MA;Seidenberg M;Rathouz PJ
识别新发局灶性和全身性特发性癫痫儿童的认知表型，并确定其与癫痫综合征、脑结构、神经发育史和家族特征的关系。138例新发癫痫患儿和95例对照组（年龄8-18岁）接受了神经心理学、临床和定量MR评估。控制参与者的神经心理学数据进行验证性因素分析，所得的因素得分，然后应用到癫痫参与者和潜在的类分析。确定的认知表型与癫痫综合征，定量神经影像学，家族和神经发育变量进行了检查。解释性因素分析确定了五个认知因素（言语，知觉，速度，注意力，执行）和潜在类别分析确定了三个集群的癫痫参与者：1）平均和可比的控制，2）多个认知领域的轻度损害，和3）严重注意力障碍的所有领域的损害，分别占癫痫样本的44%，44%和12%。认知表型成员资格与癫痫综合征无关，但与脑结构异常、父母智商和早期发育史特征的增加有关。认知表型存在于与传统癫痫综合征无关的特发性儿童癫痫中，但与脑结构、家族史和神经发育特征的测量相关。
To identify cognitive phenotypes in children with new onset focal and generalized idiopathic epilepsies and determine their relationship with epilepsy syndrome, brain structure, neurodevelopmental history and family characteristics. 138 children with new onset epilepsy and 95 controls (age 8–18) underwent neuropsychological, clinical and quantitative MR evaluations. Control participants’ neuropsychological data were subjected to confirmatory factor analysis with resultant factor scores then applied to epilepsy participants and subjected to latent class analysis. Identified cognitive phenotypes were examined in relation to epilepsy syndrome, quantitative neuroimaging, familial and neurodevelopmental variables. Confirmatory factor analysis identified five cognitive factors (verbal, perceptual, speed, attention, executive) and latent class analysis identified three clusters of epilepsy participants: 1) average and comparable to controls, 2) mild impairment across multiple cognitive domains, and 3) impairment across all domains with severe attentional impairment, representing 44%, 44% and 12% of the epilepsy sample respectively. Cognitive phenotype membership was not associated with epilepsy syndrome but was associated with increasing abnormalities in brain structure, parental IQ and features of early developmental history. Cognitive phenotypes are present in idiopathic childhood epilepsies that are unassociated with traditional epilepsy syndromes, but are associated with measures of brain structure, family history and neurodevelopmental features.