Activation of left ventricular receptors with nonmedullated vagal afferent fibers during occlusion of a coronary artery in the cat.
Activation of left ventricular receptors with nonmedullated vagal afferent fibers during occlusion of a coronary artery in the cat.
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猫冠状动脉闭塞期间，无髓迷走神经传入纤维激活左心室受体。
DOI：
10.1016/0002-9149(76)90422-7
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
P. Thoren
中科院分区：
文献类型：
--
作者：
P. Thoren
本文研究了暂时性阻断冠状动脉对15只猫左心室无髓迷走传入纤维活动的影响。从右迷走神经解剖出14根单纤维和4根细丝，其中2 ~ 3根纤维记录。它们的正常活动平均为1.8个脉冲/秒，在主动脉短暂闭塞期间，它们的活动增加到4至17个脉冲/秒，传导速度为0.6至1.3米/秒（平均0.9）。所研究的受体分布在整个心室，在实验结束时通过机械探测非跳动的心脏来确定。在冠状动脉闭塞1至1.5分钟的情况下，由该动脉供应的区域内的受体的活性与缺血区域的收缩膨胀一致地增加。活性的最初增加发生在心脏收缩期，表明受体被机械激活，而不是通过缺血区的化学变化。活动很快变得连续，达到最大值15.4脉冲/秒（平均值）。最大活动没有持续;在长达40分钟的闭塞期间，在5至10分钟后降低至5脉冲/秒（平均值）。这种减少可能是由于缺氧，因为四种测试受体中有三种在释放闭塞后显示出活性增加。
Studies were made of the effects of temporary occlusion of a coronary artery on the activity of nonmedullated afferent vagal fibers from the left ventricle of 15 cats. Recordings were made from 14 single fibers and 4 filaments with 2 to 3 fibers dissected from the right vagus. Their normal activity averaged 1.8 impulses/sec, and they were identified by an increase in activity to 4 to 17 impulses/sec during a brief occlusion of the aorta and by a conduction velocity of 0.6 to 1.3 m/sec (mean 0.9). The receptors studied were distributed throughout the ventricle, as determined by mechanical probing of the nonbeating heart at the end of the experiments. With a 1 to 1.5 minute occlusion of a coronary artery, the activity of receptors within the area supplied by that artery increased in concert with the systolic bulging of the Ischemic area. The initial increase in activity occurred during systole, suggesting that the receptors were activated mechanically rather than by chemical changes in the Ischemic zone. The activity soon became continuous, reaching a maximum of 15.4 impulses/sec (mean value). The maximal activity was not sustained; during occlusion of up to 40 minutes it decreased to 5 impulses/sec (mean value) after 5 to 10 minutes. The decrease may result from anoxia since three of four tested receptors showed an increase in activity after release of occlusion.