A Five-Gene Signature Predicts Prognosis in Patients with Kidney Renal Clear Cell Carcinoma.
A Five-Gene Signature Predicts Prognosis in Patients with Kidney Renal Clear Cell Carcinoma.
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五基因特征可预测肾透明细胞癌患者的预后
DOI：
10.1155/2015/842784
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发表时间：
2015
影响因子：
--
通讯作者：
Zhu L
中科院分区：
文献类型：
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作者：
Zhan Y;Guo W;Zhang Y;Wang Q;Xu XJ;Zhu L
肾透明细胞癌（KIRC）是全世界最常见的癌症之一，死亡率很高。许多研究提出基因可用于预测 KIRC 的预后。在这项研究中，分析了下一代测序的RNA表达数据和从癌症基因组图谱（TCGA）数据集中下载的523名患者的临床信息，以确定基因表达水平与KIRC患者预后之间的关系。确定了一组与总生存时间显着相关的五个基因，并通过 Cox 回归分析构建了包含这五个基因的模型。通过Kaplan-Meier和受试者工作特征（ROC）分析，我们证实该模型具有良好的敏感性和特异性。综上所述，五基因模型的表达与KIRC患者的预后结果相关，可能具有重要的临床意义。
Kidney renal clear cell carcinoma (KIRC) is one of the most common cancers with high mortality all over the world. Many studies have proposed that genes could be used to predict prognosis in KIRC. In this study, RNA expression data from next-generation sequencing and clinical information of 523 patients downloaded from The Cancer Genome Atlas (TCGA) dataset were analyzed in order to identify the relationship between gene expression level and the prognosis of KIRC patients. A set of five genes that significantly associated with overall survival time was identified and a model containing these five genes was constructed by Cox regression analysis. By Kaplan-Meier and Receiver Operating Characteristic (ROC) analysis, we confirmed that the model had good sensitivity and specificity. In summary, expression of the five-gene model is associated with the prognosis outcomes of KIRC patients, and it may have an important clinical significance.