Absorption of 1,3-dioleyl-2-palmitoylglycerol and intestinal flora profiles changes in mice
Absorption of 1,3-dioleyl-2-palmitoylglycerol and intestinal flora profiles changes in mice
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小鼠 1,3-二油酰-2-棕榈酰甘油的吸收和肠道菌群谱变化
DOI：
10.1080/09637486.2019.1648386
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发表时间：
2019-08-05
影响因子：
3.9
通讯作者：
Li, Chun
中科院分区：
文献类型：
--
作者：
Wang, Jing;Liu, Lihua;Li, Chun
Abstract The purpose of this study was to investigate the digestion and absorption of 1,3-dioleyl-2-palmitoylglycerol (OPO) and its effects on mineral absorption and intestinal flora in vivo. Fatty acids and mineral faeces were measured using gas chromatography-mass spectrometry and inductively coupled plasma mass spectrometry, respectively. The intestinal flora composition was assessed using high-throughput 16S rRNA sequencing. After 4-week feeding experiment, the apparent absorption rate of calcium in O group (mice fed with OPO) was 48.54 ± 0.21%, which was significantly higher than that in Z group (mice fed with mixed vegetable oil), the percentage of palmitic acid in serum of the O group mice was significantly higher. Compared with Z group, the mean relative abundance of Bifidobacteriaceae and Lactobacillaceae in the O group mice was higher. These results show that OPO can promote the absorption of fat and calcium, promote the growth of beneficial bacteria.
