Queen pheromone modulates brain dopamine function in worker honey bees
Queen pheromone modulates brain dopamine function in worker honey bees
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DOI：
10.1073/pnas.0608224104
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发表时间：
2007-02-13
影响因子：
11.1
通讯作者：
Mercer, Alison R.
中科院分区：
文献类型：
--
作者：
Beggs, Kyle T.;Glendining, Kelly A.;Mercer, Alison R.
蜂后会产生一系列复杂的化学信号（信息素），这些信号会影响巢友的行为和生理。最引人注目的是女王下颌信息素（QMP）的影响，这是一种化学混合物，可以诱导年轻的工人喂养和梳理女王，并引导蜜蜂执行与殖民地有关的任务。但是这种信息素在细胞水平上是如何运作的呢？这项研究表明，QMP对大脑中的多巴胺通路有深远的影响，这些通路在行为调节和运动控制中起着核心作用。在年轻的工蜂中，多巴胺水平，多巴胺受体基因表达水平，以及细胞对这种胺的反应都受到QMP的影响。我们确定高香子兰醇作为这些影响的一个关键因素，并提供证据表明，QMP诱导的大脑变化在行为水平上的变化。这项研究提供了令人兴奋的见解，通过QMP运作的机制和女王的能力，以调节她的后代的行为更深入的了解。
Honey bee queens produce a sophisticated array of chemical signals (pheromones) that influence both the behavior and physiology of their nest mates. Most striking are the effects of queen mandibular pheromone (QMP), a chemical blend that induces young workers to feed and groom the queen and primes bees to perform colony-related tasks. But how does this pheromone operate at the cellular level? This study reveals that QMP has profound effects on dopamine pathways in the brain, pathways that play a central role in behavioral regulation and motor control. In young worker bees, dopamine levels, levels of dopamine receptor gene expression, and cellular responses to this amine are all affected by QMP. We identify homovanillyl alcohol as a key contributor to these effects and provide evidence linking QMP-induced changes in the brain to changes at a behavioral level. This study offers exciting insights into the mechanisms through which QMP operates and a deeper understanding of the queen's ability to regulate the behavior of her offspring.