Changes in renal uptake of Tc-99m methylene diphosphonate (MDP) in stone-forming rats.
Changes in renal uptake of Tc-99m methylene diphosphonate (MDP) in stone-forming rats.
复制标题
结石形成大鼠肾摄取 Tc-99m 亚甲基二磷酸 (MDP) 的变化。
DOI：
10.1097/00004424-198411000-00013
复制
发表时间：
1984
影响因子：
6.7
通讯作者：
Schoonmaker,JE
中科院分区：
文献类型：
--
作者：
McAfee,JG;Thomas,FD;Roskopf,M;Ritter,K;Lyons,B;Lilien,OM;Schoonmaker,JE
用缺乏维生素B6的大鼠饲料制作早期肾结石模型，通过~(99m)Tc-MDP的生物分布差异，探讨是否能从对照动物中鉴别出结石。实验动物在3小时内肾脏对该制剂的平均摄取量比对照组高出约70%，但在正常范围的上限和“结石形成者”的下限之间有相当大的重叠。如果这些结果对人类有效，那么仅通过活体测量TC-99m MDP肾脏摄取不能确定男性早期结石形成疾病的代谢异常。然而，与对照组相比，形成结石的动物对MDP的骨骼摄取受到了28%到35%的抑制。因此，在“结石患者”中，肾脏和骨骼中的MDP浓度比总是高于95%的正常范围。出乎意料的是，76%的吡哆醇缺乏动物在心肌中积累的MDP高于正常范围的上限。缺乏吡哆醇的饮食对I-131河马多糖的早期生物分布或肾清除无明显影响。
A pyridoxine (vitamin B 6)-deficient diet in rats was used as a model of early renal lithiasis to find out if “stone-formers” could be identified from control animals by differences in the biodistribution of Tc-99m MDP. The mean renal uptake of this agent at 3 hours was about 70% higher in test animals than in controls, but there was considerable overlap between the upper limits of the normal range and lower values in “stone-formers.” If these results were valid for humans, the metabolic abnormality in males with early stone-forming disease could not be identified with certainty by in vivo measurements of Tc-99m MDP renal uptake alone. However, the skeletal uptake of MDP in the “stone-forming” animals was depressed by 28 to 35%, compared with control rats. Consequently, the renal to skeletal MDP concentration ratio was invariably elevated in “stone-formers” beyond the 95 percentile normal range. Unexpectedly, 76% of the pyridoxine-deficient animals had a higher accumulation of MDP in the myocardium than the upper limit of the normal range. The pyridoxine-deficient diet induced no remarkable early changes in the biodistribution or renal clearance of I-131 Hippuran.