Structural similarities and differences between the human and the mouse pancreas.
Structural similarities and differences between the human and the mouse pancreas.
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DOI：
10.1080/19382014.2015.1024405
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发表时间：
2015
期刊：
影响因子：
2.2
通讯作者：
Stožer A
中科院分区：
文献类型：
--
作者：
Dolenšek J;Rupnik MS;Stožer A
小鼠仍然是胰腺研究中研究最多的动物模型。由于这项研究的结果通常会外推到人类身上，因此了解这两个物种之间的相似性和差异是很重要的。除了两种动物器官的大小和宏观组织结构存在明显差异外，腺泡和导管外分泌组织的组织结构以及朗格汉斯内分泌胰岛的分布、组成和结构也存在一些不太明显且最近才描述的差异。此外，动脉、静脉和淋巴管以及神经支配的差异具有潜在的重要性。在这篇文章中，人类和小鼠胰腺的结构，以及它们之间的相似性和差异进行了详细的审查，在基础研究和临床应用的可能影响。
Mice remain the most studied animal model in pancreas research. Since the findings of this research are typically extrapolated to humans, it is important to understand both similarities and differences between the 2 species. Beside the apparent difference in size and macroscopic organization of the organ in the 2 species, there are a number of less evident and only recently described differences in organization of the acinar and ductal exocrine tissue, as well as in the distribution, composition, and architecture of the endocrine islets of Langerhans. Furthermore, the differences in arterial, venous, and lymphatic vessels, as well as innervation are potentially important. In this article, the structure of the human and the mouse pancreas, together with the similarities and differences between them are reviewed in detail in the light of conceivable repercussions for basic research and clinical application.