THE EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON BEHAVIORAL AND NEUROANATOMICAL COMPONENTS OF OLFACTION
THE EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON BEHAVIORAL AND NEUROANATOMICAL COMPONENTS OF OLFACTION
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DOI：
10.1016/0892-0362(92)90009-y
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发表时间：
1992-07-01
影响因子：
2.9
通讯作者：
RILEY, EP
中科院分区：
文献类型：
--
作者：
BARRON, S;RILEY, EP
出生前酒精暴露与幼鼠气味联想学习缺陷有关。这些发现的另一种解释是，而不是学习缺陷本身，酒精暴露的幼崽可能会表现出感官缺陷。本研究旨在探讨产前酒精暴露对嗅觉相关的行为和神经解剖学成分的影响。本研究中的受试者是从妊娠日（GD）6-20暴露于35%乙醇衍生卡路里（EDC）流质饮食的幼仔。包括两个对照组，0%EDC配对喂养组和随意实验室食物组。在实验1中，在3、4或10日龄的幼鼠中检查对新气味的呼吸反应。35%的EDC后代清楚地检测到气味。此外，呼吸频率存在明显的酒精相关发育延迟，如PN 3时基线呼吸频率低于对照组所示，PN 4时不再明显。实验2研究了3日龄幼鼠两个与嗅觉有关的神经解剖结构的体积，即主嗅球（MOB）和犁鼻器（VNO）。产前酒精暴露与MOB的体积减少有关，尽管VNO不受影响。
Prenatal alcohol exposure is associated with deficits in odor-associative learning in very young rat pups. One alternative explanation for these findings is that rather than a learning deficit per se, alcohol-exposed pups may display a sensory deficit. The present study was designed to examine the effects of prenatal alcohol exposure on behavioral and neuroanatomical components involved in olfaction. The subjects in this study were pups exposed to 35% ethanol-derived calorie (EDC) liquid diet from gestation days (GD) 6-20. Two control groups were included, a 0% EDC pair-fed and an ad lib lab chow group. In Experiment 1, respiratory response to a novel odor was examined in pups tested at either 3, 4, or 10 days of age. The 35% EDC offspring clearly detected the odor. Furthermore, there was an apparent alcohol-related developmental delay in respiratory rate as shown by a lower baseline respiratory rate at PN 3 relative to controls which was no longer apparent by PN 4. Experiment 2 examined the volume of two neuroanatomical structures involved in olfaction, the main olfactory bulb (MOB) and the vomeronasal organ (VNO) in 3-day-old pups. Prenatal alcohol exposure was associated with a decreased volume of the MOB although the VNO was unaffected.