The transferrin/log(ferritin) ratio: a new tool for the diagnosis of iron deficiency anemia
The transferrin/log(ferritin) ratio: a new tool for the diagnosis of iron deficiency anemia
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DOI：
10.1515/cclm-2011-0594
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发表时间：
2012-01-01
影响因子：
6.8
通讯作者：
Berendes, Paul B.
中科院分区：
文献类型：
--
作者：
Castel, Rob;Tax, Martine G. H. M.;Berendes, Paul B.
背景：血清铁蛋白是诊断缺铁性贫血（IDA）的最佳单一实验室检查。铁蛋白水平100 μ g/L通常排除IDA。然而，铁蛋白浓度在20和100 μ g/L之间通常是不确定的。本研究的目的是提高诊断IDA时铁蛋白水平是inconclusion.Methods：我们评估了经典的预测性能（铁蛋白，平均红细胞体积，转铁蛋白和血清铁）和现代[网织红细胞血红蛋白含量，血清转铁蛋白受体和可溶性转铁蛋白受体（sTfR）/log（ferr）]铁状态参数诊断IDA在2084贫血，非住院患者。结果进行了验证，在一个独立的队列274贫血patients.Results：在我们的研究人群中，29%（595例）的患者铁蛋白水平在20和100 μ g/L之间，阻碍IDA的诊断。没有一个经典的或现代的参数能够完全区分IDA人群和非IDA人群。然而，使用一个新参数，即转铁蛋白/log（铁蛋白）比，可以完全分离IDA和非IDA群体。在截止值为1.70，转铁蛋白/日志（铁蛋白）的比率表明IDA在29%的患者与不确定的铁蛋白levels.Conclusions：转铁蛋白/日志（铁蛋白）的比率是一个实用的新工具，提高诊断铁缺乏症时，铁蛋白水平是不确定的。
Background: Serum ferritin is the best single laboratory test to diagnose iron deficiency anemia (IDA). Ferritin levels 100 mu g/L usually exclude IDA. However, ferritin concentrations between 20 and 100 mu g/L are often inconclusive. The objective of this study was to improve the diagnosis of IDA when ferritin levels are inconclusive.Methods: We evaluated the predictive performance of classic (ferritin, mean corpuscular volume, transferrin and serum iron) and modern [reticulocyte hemoglobin content, serum transferrin receptor and soluble transferrin receptor (sTfR)/log(ferr)] iron status parameters to diagnose IDA in 2084 anemic, non-hospitalized patients. The results were validated in an independent cohort of 274 anemic patients.Results: In our study population, 29% (595 patients) of the patients had a ferritin level between 20 and 100 mu g/L, hampering diagnosis of IDA. None of the classic or modern parameters was capable of completely separating the IDA population from the non-IDA population. However, using a new parameter, the transferrin/log(ferritin) ratio, the IDA and non-IDA populations can be completely separated. At a cut-off value of 1.70, the transferrin/log(ferritin) ratio indicates IDA in 29% of the patients with inconclusive ferritin levels.Conclusions: The transferrin/log(ferritin) ratio is a practical new tool that improves diagnosis of iron deficiency when ferritin levels are inconclusive.