Sensitization to the psychomotor stimulant effects of amphetamine: Modulation by associative learning
Sensitization to the psychomotor stimulant effects of amphetamine: Modulation by associative learning
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DOI：
10.1037/0735-7044.110.6.1397
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发表时间：
1996-12-01
影响因子：
1.9
通讯作者：
Robinson, TE
中科院分区：
文献类型：
--
作者：
Anagnostaras, SG;Robinson, TE
作者研究了情境刺激与安非他明联合配对对精神运动致敏表达的影响。动物在特定的环境中接受d-安非他明或生理盐水。安非他明在所有环境中都产生了强烈的行为致敏，但当安非他明挑战在一个对某些组来说是新的测试环境中给予时，致敏的表达完全是特定于环境的。在安非他明配对的环境中注射生理盐水会产生条件反应（CR），但与致敏反应的大小相比，这是相当小的，并且在CR消失后，致敏反应仍然完全取决于环境。结果讨论了环境如何调节致敏表达的三种模型：兴奋性条件反射模型，抑制性条件反射模型和场合设置模型。
The authors investigated the influence of associative pairing of contextual stimuli with amphetamine administration on the expression of psychomotor sensitization. Animals received d-amphetamine or saline in group-specific environments. Amphetamine produced robust behavioral sensitization in all environments, but when an amphetamine challenge was given in a test environment that was novel for some groups but not others, the expression of sensitization was completely context specific. An injection of saline in the amphetamine-paired environment produced a conditional response (CR), but this was quite small compared to the magnitude of the sensitized response, and sensitization remained completely context specific following extinction of the CR. Results are discussed in relation to 3 models of how context may modulate the expression of sensitization: an excitatory conditioning model, an inhibitory conditioning model, and an occasion-setting model.