On distance and similarity in fold space

On distance and similarity in fold space
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DOI:
10.1093/bioinformatics/btn040
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发表时间:
2008-03-01
期刊:
影响因子:
5.8
通讯作者:
Sippl, Manfred J.
Sippl, Manfred J.
中科院分区:
生物学3区
文献类型:
--
作者:
Sippl, Manfred J.

文献摘要

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折叠空间中相似性和距离的度量信息对于结构生物信息学和结构生物学中的定量工作是必不可少的。在这里,我们从相似性的基本公理中推导出一个合适的蛋白质结构度量。度量的推导也澄清了距离和相似性的相关概念之间的关系。
Metric information on similarities and distances in fold space is essential for quantitative work in structural bioinformatics and structural biology. Here we derive a suitable metric for protein structures from the fundamental axioms of similarity. Derivation of the metric also clarifies the relationship between the interrelated concepts of distance and similarity.