FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area.
FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area.
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DOI：
10.3978/j.issn.2305-5839.2013.06.08
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发表时间：
2013-08
影响因子：
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通讯作者：
Anne von Mässenhausen;A. Franzen;L. Heasley;S. Perner
中科院分区：
文献类型：
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作者：
Anne von Mässenhausen;A. Franzen;L. Heasley;S. Perner
FGFR1扩增是最近在各种类型的癌症中鉴定的基因组畸变。特别是肺和头颈部的鳞状细胞癌显示这种高频率的遗传改变。在这些癌症中，FGFR1不仅是一个治疗靶点，而且也是一个与预后不良参数相关的生物标志物。然而，由于FGFR1扩增并不总是与高蛋白表达相关，因此定义FGFR1靶向治疗的最佳预测生物标志物非常重要。
FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.