Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014.
Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014.
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急性弛缓性脊髓炎儿童肠道病毒 D68 感染，美国科罗拉多州，2014 年。
DOI：
10.3201/eid2208.151949
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发表时间：
2016-08
影响因子：
11.8
通讯作者：
Dominguez SR
中科院分区：
文献类型：
--
作者：
Aliabadi N;Messacar K;Pastula DM;Robinson CC;Leshem E;Sejvar JJ;Nix WA;Oberste MS;Feikin DR;Dominguez SR
患有这种疾病的儿童鼻咽部病毒感染的几率是对照组的10倍。2014年8月8日-2014年10月14日期间，在美国科罗拉多丹佛附近共确定了11例急性弛缓性肌麻痹和明显神经影像学改变的儿童。10例患者出现呼吸道前驱症状，4例鼻咽部标本肠道病毒D 68（EV-D 68）阳性。为了确定EV-D 68感染和急性弛缓性肌炎之间是否存在关联，我们进行了一项回顾性病例对照研究，将这些患者与2组门诊对照儿童（1组检测急性呼吸道疾病，1组检测百日咳杆菌感染）进行比较。调整后的分析表明，对于急性弛缓性肌麻痹症儿童，EV-D 68感染的几率是急性呼吸道感染检测的10.3倍，是B检测的4.5倍。百日咳感染急性弛缓性肌炎与非EV-D 68肠道病毒或鼻病毒感染之间无统计学相关性。这些发现支持EV-D 68感染和急性弛缓性肌无力之间的关联。
Odds of this viral infection in the nasopharynx were 10 times greater for children with this condition than for controls. During August 8, 2014–October 14, 2014, a total of 11 children with acute flaccid myelitis and distinctive neuroimaging changes were identified near Denver, Colorado, USA. A respiratory prodrome was experienced by 10, and nasopharyngeal specimens were positive for enterovirus D68 (EV-D68) for 4. To determine whether an association exists between EV-D68 infection and acute flaccid myelitis, we conducted a retrospective case–control study comparing these patients with 2 groups of outpatient control children (1 group tested for acute respiratory illness and 1 for Bordetella pertussis infection). Adjusted analyses indicated that, for children with acute flaccid myelitis, the odds of having EV-D68 infection were 10.3 times greater than for those tested for acute respiratory infection and 4.5 times greater than for those tested for B. pertussis infection. No statistical association was seen between acute flaccid myelitis and non–EV-D68 enterovirus or rhinovirus infection. These findings support an association between EV-D68 infection and acute flaccid myelitis.