INTERACTION OF DIETARY FACTORS WITH ORAL ANTICOAGULANTS - REVIEW AND APPLICATIONS
INTERACTION OF DIETARY FACTORS WITH ORAL ANTICOAGULANTS - REVIEW AND APPLICATIONS
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DOI：
10.1016/s0002-8223(95)00158-1
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发表时间：
1995-05-01
影响因子：
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通讯作者：
HARRIS, JE
中科院分区：
文献类型：
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作者：
HARRIS, JE
本文回顾了已发表的关于口服抗凝剂与饮食因素相互作用的原始信息来源，指出了我们对这些相互作用的认识的不足，并建议在临床环境中应用这些信息。与许多药物-营养相互作用一样，原始参考文献包括一些实验研究和许多病例报告。在大多数情况下，确定口服抗凝剂与饮食因素的哪些相互作用具有临床相关性，并确定关于每种相互作用的适当饮食处方涉及有教育意义的意见，而不是基于广泛研究的结论。关于食物中维生素It的含量和改变凝血状态的维生素It的量，存在足够的信息，从治疗范围向患者提供关于一组食物的建议，以避免和一组食物限制在每天一份。关于可能与口服抗凝剂相互作用的其他饮食因素，患者：应注意补充维生素A、E和C以及长期使用或大量摄入酒精。
This article reviews the published original sources of information on interactions of oral anticoagulants with dietary factors, points out deficiencies in our knowledge of these interactions, and suggests applications for this information in the clinical setting. As with many drug-nutrient interactions, the original references include a few experimental studies and many case reports. Deciding which interactions of oral anticoagulants with dietary factors are clinically relevant and determining the appropriate dietary prescription concerning each interaction involves, in most cases, an educated opinion rather than a conclusion based on extensive research. Enough information exists on the vitamin It content of foods and the quantity of vitamin It that alters coagulation status from the therapeutic range to provide the patient with advice concerning a group of foods to avoid and a group of foods to limit to one serving per day. With respect to other dietary factors that may interact with oral anticoagulants, the patient: should be cautioned concerning supplements of vitamins A, E, and C and alcohol used chronically or ingested in large quantities.