Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy
Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy
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DOI：
10.1002/1531-8249(199906)45:6
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发表时间：
1999-06-01
影响因子：
11.2
通讯作者：
Hall, CD
中科院分区：
文献类型：
--
作者：
Yiannoutsos, CT;Major, EO;Hall, CD
脑脊液（CSF）中JC病毒（JCV）DNA的检测和半定量是生存的预后指标，也是进行性多灶性白质脑病（PML）病程的标志物。采用半定量聚合酶链反应（PCR）分析了15例经活检证实为PML的获得性免疫缺陷综合征（AIDS）患者的CSF样本。与高JCV负荷相比，低JCV负荷可预测更长的生存期（入组后中位生存期，24 [2-63] vs 7.6 [4-17]周）。进一步的分析表明，50至100拷贝/μ l的可能阈值区分高风险和中等风险病例。JCV负荷低于此水平的患者比JCV负荷高于此水平的患者存活时间更长。
The detection and semiquantitation of JC virus (JCV) DNA in cerebrospinal fluid (CSF) is prognostic of survival and is a marker of the course of progressive multifocal leukoencephalopathy (PML). CSF samples from 15 acquired immunodeficiency syndrome (AIDS) patients with biopsy-proven PML were analyzed by semiquantitative polymerase chain reaction (PCR). A low JCV burden was predictive of longer survival compared with a high JCV burden (median survival from entry, 24 [2-63] vs 7.6 [4-17] weeks). Further analyses indicated a possible threshold of 50 to 100 copies/mu l separating high- and moderate-risk cases. Patients with a JCV load below this level survived longer than those with a JCV load above it.