Risk of second primary cancer among esophageal cancer patients: A pooled analysis of 13 cancer registries
Risk of second primary cancer among esophageal cancer patients: A pooled analysis of 13 cancer registries
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DOI：
10.1158/1055-9965.epi-07-2876
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发表时间：
2008-06-01
影响因子：
3.8
通讯作者：
Brennan, Paul
中科院分区：
文献类型：
--
作者：
Chuang, Shu-Chun;Hashibe, Mia;Brennan, Paul
背景资料：本研究的目的是评估第二原发性癌症的风险，第一原发性食管癌以及食管癌作为第二原发性的风险，以下第一原发性癌症的其他sites.Methods：本调查是一项多中心研究，13个人口为基础的癌症登记处在欧洲，澳大利亚，加拿大和新加坡。为了评估食管癌后第二种癌症的过度发生率，我们通过将观察到的第二种癌症的数量除以根据累积人年和年龄、性别、日历期和登记特定的第一种原发性癌症发病率计算的预期癌症数量来计算标准化发病率（SIR）。在研究期间，959例第二原发癌发生在最初的食管癌之后，SIR为1.15（95%置信区间，1.08-1.22）。第二原发性胃癌与第一原发性食管腺癌相关（SIR，2.13; 95%置信区间，1.263.37）和第二原发性口腔和咽癌（6.68; 5.33-8.26），胃（1.53; 1.14-2.01），喉与食管第一原发鳞状细胞癌相关的癌基因分别为：肺癌（3.24; 1.88-5.18）、肺癌（1.55; 1.28-1.87）、肾癌（1.88; 1.18 - 2.85）和甲状腺癌（2.92; 1.18-6.02）。过量的食管癌作为第二原发性观察以下第一原发性癌症的呼吸消化道，女性乳腺癌，子宫颈，睾丸，膀胱，霍奇金淋巴瘤，和non-Hodgkin lymphoma.Conclusion：我们观察到协会的食管癌与第二原发性头颈癌和肺癌，无论多年的后续行动，这可能表明，共同的危险因素发挥了作用，在多个肿瘤的发展。
Background: The objective of this study is to assess the risk of second primary cancers following a first primary esophageal cancer as well as the risk of esophageal cancer as a second primary, following first primary cancers of other sites.Methods: The present investigation is a multicenter study of, 13 population-based cancer registries in Europe, Australia, Canada, and Singapore. To assess excess occurrence of second cancers after esophageal cancers, we calculated standardized incidence ratios (SIR) by dividing the observed numbers of second cancers by the expected number of cancers calculated from the accumulated person-years and the age-, sex-, calendar period-, and registry-specific first primary cancer incidence rates.Results: During the study period, 959 cases of second primary cancers occurred after an initial esophageal cancer, resulting in a SIR of 1.15 (95% confidence interval, 1.08-1.22). Second primary stomach cancers were associated with first primary esophageal adenocarcinomas (SIR, 2.13; 95% confidence interval, 1.263.37) and second primary cancers of the oral cavity and pharynx (6.68; 5.33-8.26), stomach (1.53; 1.14-2.01), larynx (3.24; 1.88-5.18), lung (1.55; 1.28-1.87), kidney (1.88; 1.182.85), and thyroid (2.92; 1.18-6.02) were associated with first primary squamous cell carcinomas of the esophagus. An excess of esophageal cancer as a second primary were observed following first primary cancers of the aerodigestive tract, female breast, cervix, testis, bladder, Hodgkin's lymphoma, and non-Hodgkin lymphoma.Conclusion: We observed associations of esophageal cancer with second primary head and neck cancers and lung cancer regardless of years of follow-up, which may suggest that common risk factors play a role in multiple tumor development.