NAFLD prevalence differs among hispanic subgroups: The multi-ethnic study of atherosclerosis
NAFLD prevalence differs among hispanic subgroups: The multi-ethnic study of atherosclerosis
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DOI：
10.3748/wjg.v20.i17.4987
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发表时间：
2014-05-07
影响因子：
4.3
通讯作者：
Foster, Temitope
中科院分区：
文献类型：
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作者：
Fleischman, Michael Wayne;Budoff, Matthew;Foster, Temitope
目的：为了比较非酒精性脂肪性肝病（NAFLD）的患病率之间的西班牙裔墨西哥人和西班牙裔多米尼加人和波多黎各origin.METHODS：我们评估了NAFLD的患病率之间的两个最大的亚群的西班牙裔美国人;西班牙裔墨西哥人和西班牙裔加勒比海地区的起源（多米尼加和波多黎各），在动脉粥样硬化（梅萨）队列的多种族研究。梅萨是一项大型、基于人群的多中心队列研究，包括6814名45-84岁的健康高加索人、非洲裔美国人、西班牙裔和亚洲男性和女性。我们利用2000年至2002年之间获得的基线血清，人体测量和放射学测量。NAFLD通过计算机断层扫描测量，定义为肝脏/脾脏衰减比<1。结果：排除后，共有788名西班牙裔参与者纳入研究。NAFLD的患病率为29%（n = 225）。墨西哥裔西班牙人NAFLD患病率（33%）显著高于多米尼加裔西班牙人（16%）（P < 0.01）和波多黎各裔西班牙人（18%）（P < 0.01）。在控制了年龄、性别、体重指数、腰围、高血压、血清高密度脂蛋白、甘油三酯和C反应蛋白水平以及胰岛素抵抗等因素后，墨西哥裔的西班牙人患NAFLD的可能性仍显著高于多米尼加裔和波多黎各裔。在控制以下因素后，墨西哥裔美国西班牙裔人的NAFLD患病率显著高于多米尼加裔或波多黎各裔美国西班牙裔人。已知的风险因素。在西班牙裔人群中进行风险评估时应注意不要假设同质性。(C)2014百世登出版集团有限公司有限公司All rights reserved.
AIM: To compare prevalence rates of non-alcoholic fatty liver disease (NAFLD) between Hispanics of Mexican origin and Hispanics of Dominican and Puerto Rican origin.METHODS: We evaluated prevalence rates of NAFLD between the two largest sub-populations of Hispanics in the United States; Hispanics of Mexican origin and Hispanics of Caribbean origin (Dominican and Puerto Rican), in the multi-ethnic study of atherosclerosis (MESA) cohort. MESA is a large, population based, multi-center cohort study comprised of 6814 healthy Caucasian, African-American, Hispanic, and Asian men and women aged 45-84. We utilized the baseline serum, anthropometric and radiographic measurements obtained between 2000 and 2002. NAFLD was measured via computed tomography scan and was defined as liver/spleen attenuation ratio < 1.RESULTS: There were 788 Hispanic participants included in the study after exclusions. The prevalence of NAFLD was 29% (n = 225). Hispanics of Mexican origin had a significantly higher prevalence of NAFLD (33%), compared to Hispanics of Dominican origin (16%), (P < 0.01) and Hispanics of Puerto Rican origin (18%), (P < 0.01). After controlling for age, sex, BMI, waist circumference, hypertension, serum HDL, triglyceride and CRP level and insulin resistance, Hispanics of Mexican origin remained significantly more likely to have NAFLD than those of Dominican and Puerto Rican origin.CONCLUSION: United States Hispanics of Mexican origin have a significantly higher prevalence of NAFLD when compared to United States Hispanics of Dominican or Puerto Rican origin after controlling for known risk factors. Care should be taken when performing risk assessment in Hispanic populations not to make assumptions of homogeneity. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.