NG-monomethyl L-arginine is a non-specific inhibitor of vascular relaxation.
NG-monomethyl L-arginine is a non-specific inhibitor of vascular relaxation.
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NG-monomethyl L-arginine 是一种非特异性血管舒张抑制剂。
DOI：
10.1016/0014-2999(89)90148-9
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发表时间：
1989
影响因子：
5
通讯作者：
Ramwell,PW
中科院分区：
文献类型：
--
作者：
Thomas,G;Cole,EA;Ramwell,PW
我们先前报道L-精氨酸仅在极高浓度（>/10-3 M）时才能促进血管舒张，并且这种作用部分由内皮介导（托马斯等人，1989年）。随后的报告（Rees等人，1989）暗示L-精氨酸是内皮依赖性舒张因子（EDRF）的可能前体，并且部分基于L-精氨酸对由获得30-50%的舒张引起的血管收缩的拮抗作用。羟胺是鸟苷酸环化酶的激活剂，可松弛大鼠主动脉，这种作用可被NMMA拮抗（图1A）。NMMA对硝普钠诱导的舒张的拮抗作用显示在图1B中。这种药物产生NO并激活可溶性鸟苷酸环化酶。类似NG-单甲基L-精氨酸（NMMA）。该化合物被认为是~* I内皮依赖性舒张的特异性抑制剂（Rees等人，1989年）。在这里，我们报告NMMA不是一个特异性拮抗剂，因为它也拮抗由广泛的COM- T T介导的血管舒张作用。
We reported previously that L-arginine elicits vascular relaxation only at extremely high concentrations (>/10-3 M) and this effect is partially mediated by the endothelium (Thomas et al., 1989). Subsequent reports (Rees et al., 1989) implicate L-arginine as a possible precursor of the endothelium-dependent relaxing factor (EDRF) and are based partially on the antagonistic effects of L-arginine on the vasoconstriction elicited by that a relaxation between 30-50% was obtained. Hydroxylamine, an activator of guanylate cyclase, relaxes rat aorta and this effect is antagonized by NMMA (fig. 1A). The antagonistic effect of NMMA on sodium nitroprusside-induced relaxation is shown in fig. lB. This drug generates NO and activates soluble guanylate cyclase. SimilarNG-monomethyl L-arginine (NMMA). This com- s, P pound is believed to be a specific inhibitor of~* I endothelium-dependent relaxation (Rees et al., 1989). Here, we report that NMMA is not a specific antagonist since it also antagonizes the vasodilation mediated by a wide range of com- T T