A case-control study in Hiroshima and Nagasaki examining non-radiation risk factors for thyroid cancer.
A case-control study in Hiroshima and Nagasaki examining non-radiation risk factors for thyroid cancer.
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DOI：
10.2188/jea.17.76
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发表时间：
2007-05
影响因子：
4.7
通讯作者：
Kodama K
中科院分区：
文献类型：
--
作者：
Nagano J;Mabuchi K;Yoshimoto Y;Hayashi Y;Tsuda N;Land C;Kodama K
由于对日本甲状腺癌的病因学知之甚少，我们进行了一项甲状腺癌与生活方式和其他危险因素的病例对照研究。本报告侧重于病史、家族史、吸烟和饮酒及其与辐射照射的相互作用。病理学家对1970-1986年期间报告给广岛和长崎肿瘤登记处的甲状腺癌病例进行了组织学审查。对于362例在<75岁时诊断为乳头状或滤泡状腺癌的病例，从寿命研究队列或后代队列中选择一名在城市、性别、出生年份和原子弹辐射暴露方面匹配的无癌症对照。队列研究对象是广岛和长崎的居民，有或没有原子弹辐射暴露。有关风险因素的资料是通过1986-1988年进行的预先结构化访谈获得的。条件Logistic回归分析显示，甲状腺肿或甲状腺结节史和癌症家族史与甲状腺癌的优势比增加显著相关。吸烟和饮酒与降低的比值比显著独立相关。吸烟和饮酒之间的相互作用是不明显的基础上，无论是添加剂模型或乘法模型。辐射暴露并没有显著改变这些因素与甲状腺癌风险之间的关联。甲状腺肿大/结节史和癌症家族史是甲状腺癌的危险因素。吸烟和饮酒与风险降低独立相关。自我报告的回顾性信息在解释数据方面存在一些局限性。
Because little is known about the etiology of thyroid cancer in Japan, we conducted a case-control study of thyroid cancer and lifestyle and other risk factors. The present report focuses on medical history, family history, smoking and alcohol drinking, and their interactions with radiation exposure. Thyroid cancer cases reported to the Hiroshima and Nagasaki tumor registries during 1970-1986 were histologically reviewed by pathologists. For each of 362 cases with papillary or follicular adenocarcinoma diagnosed at <75 years of age, one control without cancer matched on city, sex, year of birth, and atomic-bomb radiation exposure was selected from the Life Span Study cohort or the offspring cohort. The cohort subjects were residents of Hiroshima and Nagasaki with or without atomic-bomb radiation exposure. Information on risk factors was obtained through a pre-structured interview carried out in 1986-1988. Analysis using conditional logistic regression showed history of goiter or thyroid nodule and family history of cancer to be significantly associated with an increased odds ratio for thyroid cancer. Smoking and alcohol drinking were significantly and independently associated with a reduced odds ratio. Interaction between smoking and alcohol drinking was not evident based on either an additive model or a multiplicative model. Radiation exposure did not significantly modify the associations between these factors and thyroid cancer risk. History of goiter/nodule and family history of cancer were risk factors for thyroid cancer. Smoking and alcohol drinking were independently associated with reduced risk. Self-reported retrospective information presents some limitations in interpretation of the data.