TESTING FOR HETEROGENEITY OF RECOMBINATION FRACTION VALUES IN HUMAN GENETICS
TESTING FOR HETEROGENEITY OF RECOMBINATION FRACTION VALUES IN HUMAN GENETICS
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DOI：
10.1111/j.1469-1809.1963.tb00210.x
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发表时间：
1963-01-01
影响因子：
1.9
通讯作者：
SMITH, CAB
中科院分区：
文献类型：
--
作者：
SMITH, CAB
描述了一种使用似然值的比较来检测人类数据中重组分数值的异质性的方法。它适用于Morton（1956）以前考虑的椭圆形红细胞增多症和恒河猴的数据，以及Bannerman和Renwick（1962）报道的一些新数据。Morton关于存在异质性的结论得到了新检验的支持。这些数据似乎最好用家庭由两组组成的假设来解释。在一个，约20至90%的整体，椭圆形红细胞增多症的基因座是紧密连锁的恒河猴，重组分数是0.01和0.1之间。在另一种情况下，这两个位点是不连锁的。
A method is described for the detection of heterogeneity of recombination fraction values in human data, using a comparison of likelihood values. It is applied to the data on elliptocytosis and rhesus previously considered by Morton (1956), together with some new data reported by Bannerman and Renwick (1962). Morton''s conclusion that there exists heterogeneity is supported by the new test. The data appears best explained by the hypothesis that the families consist of two groups. In one, about 20 to 90% of the whole, the locus for elliptocytosis is closely linked with that for rhesus, the recombination fraction being between 0.01 and 0.1. In the other, the two loci are unlinked.