A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence.
A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence.
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DOI：
10.1002/npr2.12001
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发表时间：
2018-03
影响因子：
2.5
通讯作者：
Ikeda K
中科院分区：
文献类型：
--
作者：
Sugaya N;Ogai Y;Aikawa Y;Yumoto Y;Takahama M;Tanaka M;Haraguchi A;Umeno M;Ikeda K
这项前瞻性、随机、对照、评估者盲法研究调查了G蛋白激活的内向整流钾（GIRK）通道抑制剂艾芬地尔对酒精依赖患者饮酒情况的影响。
参与者是68名酒精依赖的门诊患者，他们被分配到艾芬地尔组（每天服用60毫克艾芬地尔，持续3个月）或对照组（每天服用600毫克抗坏血酸和泛酸钙，持续3个月）。参与者完成了一份问卷，其中包括研究期前（时间1）和研究开始3个月后（时间2）的饮酒频率以及重度饮酒情况。饮酒评分是根据这两项计算得出的。
从46名参与者（艾芬地尔组25名，对照组21名）中获得了有效数据。在对时间1的评分和一些协变量进行调整后，艾芬地尔组在时间2的饮酒评分显著低于对照组。对多重填补数据集的意向性治疗分析显示了类似的结果。在多重填补数据集中饮酒频率的组间差异显著，但在46名参与者中不显著。艾芬地尔组在时间2的重度饮酒率显著低于对照组。
这项研究发现艾芬地尔对酒精依赖患者的饮酒情况有抑制作用。结果支持了GIRK通道抑制剂可改善酒精依赖这一假设。
该试验在日本临床试验注册中心（UMIN000006347）注册。
目前这项前瞻性、随机、对照、评估者盲法研究调查了G蛋白激活的内向整流钾（GIRK）通道抑制剂艾芬地尔对酒精依赖患者饮酒情况的影响。这项研究发现艾芬地尔对酒精依赖患者的饮酒情况有抑制作用。结果支持了GIRK通道抑制剂可改善酒精依赖这一假设。
This prospective, randomized, controlled, rater‐blinded study investigated the effect of G protein‐activated inwardly rectifying potassium (GIRK) channel inhibitor ifenprodil on alcohol use in patients with alcohol dependence. The participants were 68 outpatients with alcohol dependence who were assigned to an ifenprodil group (administered 60 mg ifenprodil per day for 3 months) or control group (administered 600 mg ascorbic acid and calcium pantothenate per day for 3 months). The participants completed a questionnaire that included the frequency of alcohol drinking and presence of heavy drinking before the study period (time 1) and 3 months after the start of the study period (time 2). The alcohol use score was calculated using these two items. Valid data were obtained from 46 participants (25 in the ifenprodil group and 21 in the control group). The alcohol use score at time 2 in the ifenprodil group was significantly lower than that in the control group after adjusting for the score at time 1 and some covariates. The intention‐to‐treat analysis of multiply imputed datasets indicated similar results. Group differences in the frequency of alcohol drinking were significant in the multiply imputed datasets but not in 46 participants. The ifenprodil group had a significantly lower rate of heavy drinking at time 2 than the control group. This study found an inhibitory effect of ifenprodil on alcohol use in patients with alcohol dependence. The results support the hypothesis that GIRK channel inhibitors ameliorate alcohol dependence. This trial was registered in the UMIN clinical trial registry (UMIN000006347). The present prospective, randomized, controlled, rater‐blinded study investigated the effect of G protein‐activated inwardly rectifying potassium (GIRK) channel inhibitor ifenprodil on alcohol use in patients with alcohol dependence. This study found an inhibitory effect of ifenprodil on alcohol use in patients with alcohol dependence. The results support the hypothesis that GIRK channel inhibitors ameliorate alcohol dependence.
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影响因子：
25
作者：
Lewohl, JM;Wilson, WR;Harris, RA
通讯作者：
Harris, RA
DOI：
10.1016/j.jclinepi.2010.03.004
发表时间：
2010-01-01
期刊：
Open medicine : a peer-reviewed, independent, open-access journal
影响因子：
--
作者：
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作者：
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3.2
作者：
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通讯作者：
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作者：
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通讯作者：
Lehert, Philippe