Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumes
Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumes
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DOI：
10.1016/j.pscychresns.2005.01.002
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发表时间：
2005-02-28
影响因子：
2.3
通讯作者：
Weiner, MW
中科院分区：
文献类型：
--
作者：
Cardenas, VA;Studholme, C;Weiner, MW
本研究的目的是测量慢性主动性重度饮酒是否与非寻求治疗的男性和女性的脑容量损失相关，并评估问题饮酒的阳性家族史对重度饮酒者脑结构的影响。自动图像处理被用来分析高分辨率T1加权磁共振图像从49个活跃的重度饮酒者和49个年龄和性别匹配的轻度饮酒者，产生灰质，白色物质和脑脊液（CSF）的体积在额叶，颞叶，顶叶和枕叶。区域脑容量的措施进行了比较，作为一个功能的组，性别和它们的相互作用。在重度饮酒者中，饮酒量与饮酒量相关，并作为问题饮酒家族史的函数进行比较。变形形态计量学探讨了与大量饮酒或严重饮酒相关的局部萎缩模式。我们发现，与轻度饮酒者相比，重度饮酒者的灰质体积明显减少，但白色物质没有减少。与男性相比，女性有较大的灰质和较小的白色物质和CSF体积占颅内穹窿的百分比。在重度饮酒者中，较小的灰质体积与当前较高的饮酒水平和年龄相关，而问题饮酒的阳性家族史与较小的CSF体积相关。未接受酒精中毒治疗的社区重度饮酒者有剂量相关的灰质体积损失，问题饮酒的家族史改善了重度饮酒的一些结构性后果。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
The goals of this study were to measure if chronic active heavy drinking is associated with brain volume loss in nontreatment seeking men and women, and to assess the effect of positive family history of problem drinking on brain structure in heavy drinkers. Automated image processing was used to analyze high-resolution T1-weighted magnetic resonance images from 49 active heavy drinkers and 49 age- and sex-matched light drinkers, yielding gray matter, white matter and cerebrospinal fluid (CSF) volumes within the frontal, temporal, parietal and occipital lobes. Regional brain volume measures were compared as a function of group, sex and their interaction. Within heavy drinkers, volumes were correlated with measures of alcohol consumption and compared as a function of family history of problem drinking. Deformation morphometry explored localized patterns of atrophy associated with heavy drinking or severity of drinking. We found significant gray matter volume losses, but no white matter losses, in active heavy drinkers compared with light drinkers. Women had greater gray matter and smaller white matter and CSF volumes as a percentage of intracranial vault than men. Within heavy drinkers, smaller gray matter volumes were associated with higher current levels of drinking and older age, while a positive family history of problem drinking was associated with smaller CSF volumes. Community-dwelling heavy drinkers who are not in alcoholism treatment have dose-related gray matter volume losses, and family history of problem drinking ameliorates some structural consequences of heavy drinking. (c) 2005 Elsevier Ireland Ltd. All rights reserved.