The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals
The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals
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DOI：
10.1016/j.physbeh.2004.08.019
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发表时间：
2004-11-15
影响因子：
2.9
通讯作者：
Melis, MR
中科院分区：
文献类型：
--
作者：
Argiolas, A;Melis, MR
下丘脑的室旁核包含一组投射到下丘脑外脑区域和脊髓的催产素能神经元的细胞体，这些神经元参与勃起功能和交配的控制。在雄性大鼠中，这些神经元可以被多巴胺、兴奋性氨基酸、一氧化氮（NO）、海沙瑞林类似肽和催产素本身激活，以诱导阴茎勃起并促进交配，而它们被γ-氨基丁酸（GABA）和GABA激动剂以及阿片肽和阿片类药物抑制则抑制性反应。多巴胺、催产素、兴奋性氨基酸和海沙瑞林类似肽对室旁催产素能神经元的激活显然是由一氧化氮（NO）合酶的激活介导的。 NO 反过来又通过一种尚未确定的机制激活下丘脑外脑区催产素能神经元释放催产素。室旁催产素能神经元和与上述报道类似的机制也参与生理环境中阴茎勃起的表达，即当男性因难以接近的接受性女性的存在而诱导阴茎勃起时，这被认为是男性心因性阳痿的模型，以及在交配期间。这些发现表明，投射到下丘脑外脑区、脊髓和室旁核的室旁催产素能神经元在哺乳动物勃起功能和雄性性行为的控制中发挥重要作用。 (C) 2004 Elsevier Inc. 保留所有权利。
The paraventricular nucleus of the hypothalamus contains the cell bodies of a group of oxytocinergic neurons projecting to extraltypothalamic brain areas and to the spinal cord, which are involved in the control of erectile function and copulation. In male rats, these neurons can be activated by dopamine, excitatory amino acids, nitric oxide (NO), hexarelin analogue peptides and oxytocin itself to induce penile erection and facilitate copulation, while their inhibition by gamma-aminobutyric acid (GABA) and GABA agonists and by opioid peptides and opiate-like drugs inhibits sexual responses. The activation of paraventricular oxytocinergic neurons by dopamine, oxytocin, excitatory amino acids and hexarelin analogue peptides is apparently mediated by the activation of nitric oxide (NO) synthase. NO in turn activates, by a mechanism that is as yet unidentified, the release of oxytocin from oxytocinergic neurons in extrahypothalamic brain areas. Paraventricular oxytocinergic neurons and mechanisms similar to those reported above are also involved in the expression of penile erection in physiological contexts, namely, when penile erection is induced in the male by the presence of an inaccessible receptive female, which is considered a model for psychogenic impotence in man, as well as during copulation. These findings show that paraventricular oxytocinergic neurons projecting to extrahypothalamic brain areas and to the spinal cord and the paraventricular nucleus play an important role in the control of erectile function and male sexual behaviour in mammals. (C) 2004 Elsevier Inc. All rights reserved.