Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?
Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?
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DOI：
10.1183/23120541.00542-2020
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发表时间：
2020-10-01
影响因子：
4.6
通讯作者：
Spruit, Martijn A.
中科院分区：
文献类型：
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作者：
Goertz, Yvonne M. J.;Van Herck, Maarten;Spruit, Martijn A.
背景：许多COVID-19患者不需要住院治疗，也不需要接受COVID-19检测。有轶事证据表明，“轻度”COVID-19患者可能会抱怨持续的症状，甚至在感染后几周。这表明感染期间的症状可能不会自发消退。本研究的目的是评估住院和非住院COVID-19患者在症状发作后多种相关症状是否恢复。方法：共有2113名荷兰和比利时持续投诉的冠状病毒患者的Facebook小组成员，以及在荷兰肺脏基金会网站上注册的一组人，进行了人口统计学评估，既存合并症、健康状况、症状发作日期、COVID-19诊断、医疗保健利用以及症状发作时存在29种症状（回顾性）和随访时（平均值+/- SD 79 +/- 17天后症状发作）。总体而言，分析了112名住院患者和2001名非住院患者（确诊COVID-19，n=345;基于COVID-19，n=882;和疑似COVID-19，n=774）。随着时间的推移，感染期间症状的中位数显著减少（中位数（四分位距）14（11-17）对6（4-9）; p
Background: Many patients with COVID-19 did not require hospitalisation, nor underwent COVID-19 testing. There is anecdotal evidence that patients with "mild" COVID-19 may complain about persistent symptoms, even weeks after the infection. This suggests that symptoms during the infection may not resolve spontaneously. The objective of this study was to assess whether multiple relevant symptoms recover following the onset of symptoms in hospitalised and nonhospitalised patients with COVID-19.Methods: A total of 2113 members of two Facebook groups for coronavirus patients with persistent complaints in the Netherlands and Belgium, and from a panel of people who registered on a website of the Lung Foundation Netherlands, were assessed for demographics, pre-existing comorbidities, health status, date of symptoms onset, COVID-19 diagnosis, healthcare utilisation, and the presence of 29 symptoms at the time of the onset of symptoms (retrospectively) and at follow-up (mean +/- SD 79 +/- 17 days after symptoms onset).Results: Overall, 112 hospitalised patients and 2001 nonhospitalised patients (confirmed COVID-19, n=345; symptom-based COVID-19, n=882; and suspected COVID-19, n=774) were analysed. The median number of symptoms during the infection reduced significantly over time (median (interquartile range) 14 (11-17) versus 6 (4-9); p