Arginine methylation of hnRNP K enhances p53 transcriptional activity
Arginine methylation of hnRNP K enhances p53 transcriptional activity
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DOI：
10.1016/j.febslet.2008.04.051
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发表时间：
2008-05-28
期刊：
影响因子：
3.5
通讯作者：
Hu, Gengxi
中科院分区：
文献类型：
--
作者：
Chen, Yibin;Zhou, Xinyuan;Hu, Gengxi
以前的研究表明，hnRNP K作为P53的辅助因子，在协调DNA损伤的转录反应中起着关键作用，它可以在精氨酸残基上甲基化。在这项研究中，我们观察到hnRNP K在紫外线辐射下显著的精氨酸甲基化。此外，hnRNP K的精氨酸甲基化增强了其与P53的亲和力。抑制hnRNP K的甲基化可减弱P53对p21启动子的募集，降低P53的转录活性。这些数据表明，hnRNP K的精氨酸甲基化是P53转录活性的关键因素。(C)2008年，由Elsevier B.V.代表欧洲生化学会联合会出版。
Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53. In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation. Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53. Inhibition of methylation in hnRNP K attenuated the recruitment of p53 to p21 promoter, and reduced p53 transcriptional activity. These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity. (C) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.