PID: the Pathway Interaction Database
PID: the Pathway Interaction Database
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DOI：
10.1093/nar/gkn653
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发表时间：
2009-01-01
影响因子：
14.9
通讯作者：
Buetow, Kenneth H.
中科院分区：
文献类型：
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作者：
Schaefer, Carl F.;Anthony, Kira;Buetow, Kenneth H.
途径相互作用数据库（PID，pid.nci.nih.gov）是由人类分子信号传导和调控事件以及关键细胞过程组成的策划和同行评审途径的免费集合。该数据库由美国国家癌症研究所和自然出版集团合作创建，是癌症研究界和其他对细胞通路感兴趣的人（如神经科学家，发育生物学家和免疫学家）的研究工具。PID提供了一系列搜索功能，以促进路径探索。用户可以浏览预定义的路径集或创建以单个分子或感兴趣的细胞过程为中心的相互作用网络图。此外，批量查询工具允许用户上传分子的长列表，例如来自微阵列实验的分子，并将这些分子覆盖到预定义的途径上或可视化完整的分子连接图。用户还可以下载可扩展标记语言（XML）和生物途径交换（BioPAX）2级格式的分子列表，引文列表和完整的数据库内容。该数据库每月更新新的途径内容，并由专门委托撰写的关于其他相关在线工具实际使用情况的文章予以补充。
The Pathway Interaction Database (PID,http://pid.nci.nih.gov) is a freely available collection of curated and peer-reviewed pathways composed of human molecular signaling and regulatory events and key cellular processes. Created in a collaboration between the US National Cancer Institute and Nature Publishing Group, the database serves as a research tool for the cancer research community and others interested in cellular pathways, such as neuroscientists, developmental biologists and immunologists. PID offers a range of search features to facilitate pathway exploration. Users can browse the predefined set of pathways or create interaction network maps centered on a single molecule or cellular process of interest. In addition, the batch query tool allows users to upload long list(s) of molecules, such as those derived from microarray experiments, and either overlay these molecules onto predefined pathways or visualize the complete molecular connectivity map. Users can also download molecule lists, citation lists and complete database content in extensible markup language (XML) and Biological Pathways Exchange (BioPAX) Level 2 format. The database is updated with new pathway content every month and supplemented by specially commissioned articles on the practical uses of other relevant online tools.