Menin dynamics and functional insight: Take your partners
Menin dynamics and functional insight: Take your partners
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DOI：
10.1016/j.mce.2010.04.011
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发表时间：
2010-09-15
影响因子：
4.1
通讯作者：
Racz, Karoly
中科院分区：
文献类型：
--
作者：
Balogh, Katalin;Patocs, Attila;Racz, Karoly
尽管最近有大量的发现和新奇发现，但由导致多发性内分泌瘤1型综合征的基因编码的蛋白质薄荷素仍然是一个谜。虽然我们对它的相互作用和功能有了广泛的了解，但似乎我们仍然看不到故事的全部复杂性。作者从MEN1基因转录和翻译的调控到脑膜素在核内外的作用，总结了有关脑膜素动力学和功能的最新发现和以前的基础知识，重点介绍了关于其与核受体相互作用的可能作用的新数据。(C)2010年，爱思唯尔爱尔兰有限公司出版。
Despite the large number of recent findings and novelties, menin, the protein encoded by the gene responsible for multiple endocrine neoplasia type 1 syndrome, still remains a mystery. Although we have extensive knowledge about its interactions and functions, but it seems that we still cannot see the story in its full complexity. Here, the authors summarize recent findings and former basics on menin dynamics and function by following the way from regulation of MEN1 gene transcription and translation towards the role of menin within and outside of the nucleus, highlighting new data on the possible role of its interactions with nuclear receptors. (C) 2010 Published by Elsevier Ireland Ltd.