Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder.
Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder.
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DOI：
10.1001/jamaneurol.2015.0248
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发表时间：
2015-07
期刊：
影响因子：
29
通讯作者：
O'Connor K
中科院分区：
文献类型：
--
作者：
Kremer S;Renard F;Achard S;Lana-Peixoto MA;Palace J;Asgari N;Klawiter EC;Tenembaum SN;Banwell B;Greenberg BM;Bennett JL;Levy M;Villoslada P;Saiz A;Fujihara K;Chan KH;Schippling S;Paul F;Kim HJ;de Seze J;Wuerfel JT;Guthy-Jackson Charitable Foundation (GJCF) Neuromyelitis Optica (NMO) International Clinical Consortium and Biorepository;Cabre P;Marignier R;Tedder T;van Pelt D;Broadley S;Chitnis T;Wingerchuk D;Pandit L;Leite MI;Apiwattanakul M;Kleiter I;Prayoonwiwat N;Han M;Hellwig K;van Herle K;John G;Hooper DC;Nakashima I;Sato D;Yeaman MR;Waubant E;Zamvil S;Stüve O;Aktas O;Smith TJ;Jacob A;O'Connor K
在视神经肌萎缩（NMO）谱系障碍患者的常规磁共振成像（MRI）扫描中经常观察到脑实质病变，但尚未确定将其与其他疾病引起的病变明确区分开来的特定形态学和时间模式。该文献综述总结了NMO频谱障碍患者报告的先进定量成像措施的文献，包括质子MR波谱、扩散张量成像、磁化传递成像、定量MR体积测定和超高场强MRI。它是考虑先进的MRI技术用于患者的NMO由不同的专家在该领域。虽然定量测量，如质子磁共振波谱或磁化传递成像没有重复显示弥漫性脑损伤，初步数据从扩散加权成像和脑组织体积测定表明更多的白色物质比灰质降解。这些发现可以通过超高场MRI证实。使用非传统的MRI技术，可以进一步了解的致病过程中的NMO频谱障碍，并可能帮助我们确定不同的放射学特征对应于这种疾病的特定表型表现。
Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.