Immunophenotypic analysis of peripheral blood leukocytes at different stages of HIV infection. An analysis of asymptomatic, ARC, and AIDS populations.
Immunophenotypic analysis of peripheral blood leukocytes at different stages of HIV infection. An analysis of asymptomatic, ARC, and AIDS populations.
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HIV感染不同阶段外周血白细胞的免疫表型分析。
DOI：
10.1093/ajcp/92.3.300
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发表时间：
1989
影响因子：
3.5
通讯作者：
Parker,JW
中科院分区：
文献类型：
--
作者：
Formenti,SC;Turner,RR;deMartini,RM;Boone,DC;Bishop,PC;Levine,AM;Parker,JW
使用单克隆抗体和流式细胞术对 51 名获得性免疫缺陷综合征 (AIDS) 或艾滋病相关综合征 (ARC) 患者的血液白细胞进行了免疫表型分析。这些患者被分为四个临床定义的组：HIV 阳性无症状组（HIV+/A，8）；持续性全身性腺病 (14)；卡波西肉瘤 (12)；和机会性感染（17）。比较组间的免疫表型。在绝对淋巴细胞计数、总 T 细胞、辅助/诱导 T 细胞、CD4+ 淋巴细胞的辅助诱导子亚群、CD4+ 淋巴细胞的抑制诱导子亚群、激活的辅助 T 细胞和自然杀伤细胞方面观察到统计学显着差异。 CD8+细胞和子集在各组之间没有统计学差异，可能被大范围掩盖，但中值表明存在差异。结果表明，随着艾滋病毒感染的进展，某些亚群的数量会出现增加或减少的模式。
Blood leukocytes from 51 patients with acquired immune deficiency syndrome (AIDS) or AIDS-related syndrome (ARC) were immunophenotyped with the use of monoclonal antibodies and flow cytometry. The patients were placed into four clinically defined groups: HIV-positive asymptomatic (HIV+/A, 8); persistent generalized adenopathy (14); Kaposi’s sarcoma (12); and opportunistic infections (17). Immiinophenotypes were compared between groups. Statistically significant differences were seen in absolute lymphocyte counts, total T-cells, helper/inducer T-cells, the helper inducer subset of CD4+lymphocytes, the suppressor inducer subset of CD4+lymphocytes, activated helper T-cells, and natural killer cells. CD8+cells and subsets were not statistically different between groups, possibly obscured by large ranges, but median values suggested differences. Results indicate a pattern of increasing or decreasing numbers of certain subpopulations as HIV infection progresses.