Sensory modality-specific homeostatic plasticity in the developing optic tectum
Sensory modality-specific homeostatic plasticity in the developing optic tectum
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DOI：
10.1038/nn.2772
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发表时间：
2011-05-01
影响因子：
25
通讯作者：
Aizenman, Carlos D.
中科院分区：
文献类型：
--
作者：
Deeg, Katherine E.;Aizenman, Carlos D.
我们在非洲爪蟾蝌蚪视顶盖的多感觉神经元中发现了一种以前未知的稳态突触可塑性形式。已知单个顶盖神经元接收来自多种感觉方式的汇聚输入。我们观察到体内视觉或机械感觉活动的长期变化会导致每种感觉方式特有的稳态变化。与典型形式的稳态突触可塑性（例如突触缩放）相比，我们发现这种类型的可塑性以特定路径的方式发生，更让人想起赫布型可塑性。
We found a previously unknown form of homeostatic synaptic plasticity in multisensory neurons in the optic tectum of Xenopus laevis tadpoles. Individual tectal neurons are known to receive converging inputs from multiple sensory modalities. We observed that long-term alterations in either visual or mechanosensory activity in vivo resulted in homeostatic changes specific to each sensory modality. In contrast with typical forms of homeostatic synaptic plasticity, such as synaptic scaling, we found that this type of plasticity occurred in a pathway-specific manner that is more reminiscent of Hebbian-type plasticity.