EFFECTS OF HEROIN ON LEVER PRESSING FOR INTRACRANIAL SELF-STIMULATION, FOOD AND WATER IN RAT
EFFECTS OF HEROIN ON LEVER PRESSING FOR INTRACRANIAL SELF-STIMULATION, FOOD AND WATER IN RAT
复制标题
DOI：
10.1007/bf00421261
复制
发表时间：
1975-01-01
期刊：
影响因子：
--
通讯作者：
MEYERHOFF, JL
中科院分区：
文献类型：
--
作者：
KOOB, GF;SPECTOR, NH;MEYERHOFF, JL
雄性大鼠持续接触颅内自我刺激（ICSS）、水和食物，每天连续5次注射海洛因（5 mg/kg）。8只大鼠在注射海洛因后2-6小时，ICSS的压杆率增加。在此期间，水和食物的杠杆按压率没有显着变化。纳洛酮（5 mg/kg）预处理可使海洛因对ICSS的易化作用减弱82%。第二组的8只大鼠维持在降低ICSS率未能显示出增加杠杆按ICSS与海洛因。本研究中描述的海洛因的促进作用与先前报道的描述吗啡对ICSS影响的研究一致。
Male rats maintained with continuous access to levers for intracranial self-stimulation (ICSS), water, and food were subjected to five consecutive daily injections of heroin (5 mg/kg). Rates of lever pressing for ICSS were increased in 8 rats, 2–6 hrs after administration of heroin. Rates of lever pressing for water and food were not significantly changed during this period. Naloxone (5 mg/kg) pretreatment attenuated by 82% the facilitative effect of heroin on ICSS. A second group of 8 rats maintained at reduced ICSS rates failed to show an increase in lever pressing for ICSS with heroin. The facilitative effect of heroin described in this study is consistent with previously reported studies describing the effects of morphine on ICSS.