Effects of intraperitoneal nitroprusside on peritoneal clearances in man with variations of dose, frequency of administration and dwell times.
Effects of intraperitoneal nitroprusside on peritoneal clearances in man with variations of dose, frequency of administration and dwell times.
复制标题
腹膜内硝普钠对人体腹膜清除率的影响随剂量、给药频率和停留时间的变化而变化。
作者：
K. Nolph;A. Ghods;P. Brown;Z. Twardowski
腹膜内硝普钠的临床研究旨在检查药物对腹膜清除率的影响，作为剂量、给药频率和停留时间的函数。每升透析液添加 1 mg 硝普钠可增加清除率和蛋白质损失，且效果逐渐增强，直至最大剂量 4.5 mg/1。在连续 3 次或更多次交换后，在高剂量下观察到最大效果。在药物交换后，甚至在一些研究中，甚至在交替交换期间，清除效应迅速恢复到控制状态。对溶质清除率的比例影响似乎与停留时间无关，支持了先前表明面积渗透性变化的研究。连续 12 次或更多次交换显示血压几乎没有变化。多次交换后未检测到血清硫氰酸盐增加。透析液细胞计数未显示化学刺激的证据。
Clinical studies with intraperitoneal nitroprusside were designed to examine drug effects on peritoneal clearances as a function of dose, frequency of administration and dwell times. Increases in clearances and protein losses were seen with 1 mg of nitroprusside per liter of dialysis solution, with progressively greater effects up to maximum doses of 4.5 mg/1. Maximum effects were seen at the high dose after 3 or more consecutive exchanges. Clearance effects promptly returned toward control during postdrug exchanges and, in some studies, even during alternate exchanges. Proportional effects on solute clearances appeared independent of dwell time, supporting previous studies suggesting area permeability alterations. Series of 12 or more consecutive exchanges showed little change in blood pressure. Increases in serum thiocyanate were not detected after multiple exchanges. Dialysate cell counts showed no evidence of chemical irritation.