Integrated analyses for genetic markers of polycystic ovary syndrome with 9 case-control studies of gene expression profiles.
Integrated analyses for genetic markers of polycystic ovary syndrome with 9 case-control studies of gene expression profiles.
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多囊卵巢综合征遗传标记与9例基因表达谱病例对照研究的综合分析
DOI：
10.18632/oncotarget.13881
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发表时间：
2017-01-10
期刊：
影响因子：
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通讯作者：
Wang G
中科院分区：
文献类型：
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作者：
Lu C;Liu X;Wang L;Jiang N;Yu J;Zhao X;Hu H;Zheng S;Li X;Wang G
由于遗传异质性和可变的诊断标准，多囊卵巢综合征的遗传学研究特别具有挑战性。此外，缺乏足够大的队列限制了对多囊卵巢综合征易感基因的鉴定。在这里，我们对截至2016年8月31日存放在基因表达综合数据库中的研究进行了系统检索。目前的分析包括以下研究：1）多囊卵巢综合征患者和正常对照，2）信使RNA的基因表达谱，3）足够的数据进行分析。最终，共有9项研究（13个数据集）符合入选标准，并进行了后续综合分析。通过综合分析，有13个遗传因子在所有数据集中重叠，并确定为多囊卵巢综合征的显着特异性基因。质量控制评估后，剩余6个数据集。进一步的基因本体富集和通路分析表明，差异表达基因主要富集在卵母细胞通路中。这些发现为多囊卵巢综合征的诊断和预后提供了潜在的分子标志物，但其在多囊卵巢综合征中的确切作用和机制尚需深入研究。
Due to genetic heterogeneity and variable diagnostic criteria, genetic studies of polycystic ovary syndrome are particularly challenging. Furthermore, lack of sufficiently large cohorts limits the identification of susceptibility genes contributing to polycystic ovary syndrome. Here, we carried out a systematic search of studies deposited in the Gene Expression Omnibus database through August 31, 2016. The present analyses included studies with: 1) patients with polycystic ovary syndrome and normal controls, 2) gene expression profiling of messenger RNA, and 3) sufficient data for our analysis. Ultimately, a total of 9 studies with 13 datasets met the inclusion criteria and were performed for the subsequent integrated analyses. Through comprehensive analyses, there were 13 genetic factors overlapped in all datasets and identified as significant specific genes for polycystic ovary syndrome. After quality control assessment, there were six datasets remained. Further gene ontology enrichment and pathway analyses suggested that differentially expressed genes mainly enriched in oocyte pathways. These findings provide potential molecular markers for diagnosis and prognosis of polycystic ovary syndrome, and need in-depth studies on the exact function and mechanism in polycystic ovary syndrome.