Low Cancer Rates among Patients with Dementia in a Population-Based Register Study in Sweden
Low Cancer Rates among Patients with Dementia in a Population-Based Register Study in Sweden
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DOI：
10.1159/000315509
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发表时间：
2010-01-01
影响因子：
2.4
通讯作者：
Olsson, Hakan
中科院分区：
文献类型：
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作者：
Attner, Bo;Lithman, Thor;Olsson, Hakan
背景：一些研究表明痴呆患者的癌症发病率较低。我们进一步研究了基于人群登记的18种癌症类型。方法：在19,756例病例和147,324例年龄和性别匹配的对照中，研究了癌症诊断前9-45个月的痴呆诊断。结果：总体而言，痴呆的诊断是显着不常见的癌症病例（风险比，RR = 0.60; 95%CI = 0.52-0.69）。结论：该研究证实了先前的发现，即痴呆症患者患癌症的风险较低。由于对所有类型的肿瘤都有影响，特别是对70岁以上的患者，而且由于肿瘤位于体内的患者的缺陷更明显，因此数据表明，痴呆症患者的恶性肿瘤诊断不足。版权所有（C）2010 S. Karger AG，巴塞尔
Background: Some studies have suggested a lower incidence of cancer in patients with dementia. We studied this further for 18 cancer types in population-based registers. Methods: In 19,756 cases and in 147,324 age-and sex-matched controls a diagnosis of dementia was studied 9-45 months prior to the diagnosis of cancer. Results: Overall a diagnosis of dementia was significantly less common among the cancer cases (risk ratio, RR = 0.60; 95% Cl = 0.52-0.69). Conclusion: The study confirms previous findings that patients with dementia have a lower risk of cancer. Because the effect was seen for all tumour types and especially for patients older than 70 years and since the deficit was more pronounced for patients with tumours situated within the body, the data suggest that malignancies are underdiagnosed for persons with dementia. Copyright (C) 2010 S. Karger AG, Basel