Effect of repeated cocaine administration on detection times in oral fluid and urine
Effect of repeated cocaine administration on detection times in oral fluid and urine
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DOI：
10.1093/jat/30.7.458
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发表时间：
2006-09-01
影响因子：
2.5
通讯作者：
Sampson-Cone, Angela
中科院分区：
文献类型：
--
作者：
Jufer, Rebecca;Walsh, Sharon L.;Sampson-Cone, Angela
单次给药研究报告的检测时间可能无法预测重复可卡因给药后的检测时间。虽然重复可卡因给药可导致药物蓄积和排泄时间延长，但重复给药的对照给药研究数据很少。我们比较了单次和重复可卡因给药后口腔液中可卡因和苯甲酰芽子碱（BZE）以及尿液中BZE的检测时间。两组可卡因经验的受试者参加了这些研究。单次给药组通过静脉、鼻内和烟熏给药接受可卡因。重复剂量组接受每日递增的口服可卡因剂量，最终达到1250-2000 mg。通过气相色谱-质谱法分析末次给药后的口腔液和尿液样本。检测时间确定为至最后一份阳性标本的时间。重复给药的效果是延长口腔液检测时间可卡因约四倍和BZE检测时间七倍，而尿液BZE检测时间延长两倍。由于可卡因滥用者经常自我管理更高和重复剂量，我们的结论是，在单剂量研究中观察到的检测时间短低估了在现实环境中检测可卡因滥用的口腔液的效用。
Detection times reported for single-dose studies may not predict detection times following repeated cocaine dosing. Although repeated cocaine administration can result in drug accumulation and extended excretion time, there is a paucity of data from controlled dosing studies with repeated drug administration. We compared detection times for cocaine and benzoylecgonine (BZE) in oral fluid and BZE in urine following single and repeated cocaine dosing. Two groups of cocaine-experienced subjects participated in these studies. The single-dose group received cocaine by intravenous, intranasal, and smoked administration. The repeated dose group received daily escalating oral cocaine doses culminating in a total of 1250–2000 mg. Oral fluid and urine specimens following the last dosing were analyzed by gas chromatography-mass spectrometry. Detection times were determined as the time to the last positive specimen. The effect of repeated dosing was to extend oral fluid detection times for cocaine approximately fourfold and BZE detection times sevenfold, whereas urine BZE detection times were extended twofold. Because cocaine abusers frequently self-administer higher and repeated doses, we conclude that the short detection times observed in single-dose studies underestimate the utility of oral fluid for detection of cocaine abuse in realistic settings.